Ultra performance liquid chromatography(UPLC) coupled with orthogonal acceleration time-of-flight(oaTOF) mass spectrometry is becoming an effective and high-throughput analytical technique in metabonomics *** this pap...
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Ultra performance liquid chromatography(UPLC) coupled with orthogonal acceleration time-of-flight(oaTOF) mass spectrometry is becoming an effective and high-throughput analytical technique in metabonomics *** this paper,an UPLC-oaTOF-MS system was employed to investigate the serum profiles of 40 diabete mellitus(DM)/diabetic nephropathy(DN) patients and 25 healthy volunteers in an effort to find potential *** UPLC system produced information-rich chromatograms with typical measured peak widths of 4 s,and generated peak capacities of 225 in 15 *** the UPLC-oaTOF-MS analysis,principal component analysis(PCA) was used for group differentiation and marker *** the projection of positive mode,DM/DN patients and the controls were obviously divided into three ***,two potential markers were identified as phytosphingosine and sphinganine,*** and sphinganine with decreased concentrations in the patients,were closely related to the sphingolipid metabolism.
＜正＞金属铍（Be）是目前已知最轻的一种稳定金属,它质地坚硬、导热性好、熔点高、耐腐蚀、无磁性、对 X 射线有很高的穿透率,这些优异的物理化学性能决定了铍在工业界的广泛应用,尤其是在太空科技、核能、国防、电信工业等领域。然而...
＜正＞金属铍（Be）是目前已知最轻的一种稳定金属,它质地坚硬、导热性好、熔点高、耐腐蚀、无磁性、对 X 射线有很高的穿透率,这些优异的物理化学性能决定了铍在工业界的广泛应用,尤其是在太空科技、核能、国防、电信工业等领域。然而,金属铍及其化合物有很大毒性,吸入含铍的粉尘或烟雾会造成严重的肺部损伤,包括急性化学性肺炎和慢性铍疾病
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