Baicalin is a major bioactive ingredient from the roots of Scutellaria baicalensis Georgi and has various pharmacological actions such as anti-apoptosis and anti-oxidative ***,an involvement of baicalin in the ethanol...
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Baicalin is a major bioactive ingredient from the roots of Scutellaria baicalensis Georgi and has various pharmacological actions such as anti-apoptosis and anti-oxidative ***,an involvement of baicalin in the ethanol-induced cerebral impairment remains ***,here we explored that the neuroprotective effects of baicalin on ethanol-induced impairment in C57BL/6 mice model with Lieber-De Carli liquid diet including *** utilizing Morris water maze test,we found that baicalin attenuated the cognitive dysfunction of mice treated with *** discuss the anti-apoptosis effects of baicalin on ethanol mediated neuronal impairment,histopathological examination such as Nissl staining and Neu N immunohistochemistry,molecular biological analysis such as Western Blot and quantitative PCR were used to evaluate the apoptosis of hippocampal *** analysis of above results showed that baicalin could attenuate apoptosis of hippocampal neurons after ethanol *** explore the anti-oxidative mechanism of baicalin in hippocampal neuronal impairment caused by ethanol,the oxidative stress injury of hippocampal neurons was evaluated by measuring levels of malondialdehyde(MDA),activities of catalase(CAT),Cu/Zn-superoxide dismutase(SOD),Mn-SOD,glutathione(GSH)and glutathione peroxidase(GSH-PX).In addition,Western blot analysis showed that baicalin modulated the protein expressions of mitogen-activated protein kinases(MAPKs),including ERK,JNK and ***,these results suggest that baicalin alleviates ethanol-mediated hippocampal neuronal impairment by anti-apoptosis and anti-oxidative,and then improves cognitive function of mice treated byethanol,which is likely to be related to MAPK signal pathway.
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