Objective To analyze the influencing factors on the occurrence of anxiety and depression among secondary school students in Shanxi Province in 2023 based on the random forest algorithm and to construct a prediction mo...
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Objective To analyze the influencing factors on the occurrence of anxiety and depression among secondary school students in Shanxi Province in 2023 based on the random forest algorithm and to construct a prediction model to provide a scientific basis for preventing and controlling the occurrence of negative emotions such as anxiety and depression among secondary school students. Methods In September 2023, 104 826 secondary school students in 11 cities of Shanxi Province were selected by stratified random whole-cluster sampling method for questionnaire survey, and the Generalized Anxiety Scale(GAD-7) and the Center for Streamlined Depression Scale(CES-D) were used to investigate anxiety and depression. Epidata was used for database establishment, chi-square test was used for between-group comparisons, logistic regression was used for influencing factor analysis, and Python 3.7 was used to establish a random forest prediction model and rank the importance of each variable. Results The detection rates of anxiety and depression among secondary school students in Shanxi Province in 2023 were 33.26% and 23.72%, respectively, and were higher for girls than for boys, and higher for students in general and vocational high schools than for junior high school students. The results of multifactorial regression analysis showed that female students(OR: 1.846、1.655,95%CI: 1.794-1.901、1.602-1.710), high school(OR: 2.019、1.670,95%CI: 1.956-2.083、1.612-1.731), vocational high school(OR: 1.167、1.356,95%CI: 1.085-1.254、1.254-1.466), non-conventional family(OR: 1.105、1.248,95%CI: 1.072-1.140、1.206-1.292), living in school(OR: 1.102、1.117,95%CI: 1.070-1.136、1.080-1.155), eating fried food ≥1 time/day(OR: 1.296、1.375,95%CI: 1.227-1.369、1.297-1.457), being seriously injured(OR: 1.636、1.688,95%CI: 1.524-1.755、1.569-1.816), being bullied in school(OR: 2.315、3.411,95%CI: 2.150-2.492、3.165-3.677), being scolded by parents(OR: 2.881、3.191,95%CI: 2.766-3.001、3.059-3.328), smoking(OR: 1.344、1.435
目的探讨NAT10在肝癌中的临床意义与潜在作用机制。方法基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)获得的50例正常和374例肿瘤样本,采用R 4.2.1处理所获数据。结果NAT10在肿瘤样本中的表达显著高于正常样本(P<0.001)。与NAT1...
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目的探讨NAT10在肝癌中的临床意义与潜在作用机制。方法基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)获得的50例正常和374例肿瘤样本,采用R 4.2.1处理所获数据。结果NAT10在肿瘤样本中的表达显著高于正常样本(P<0.001)。与NAT10低表达患者比较,NAT10高表达患者预后较差(P<0.001)。Logistic回归分析结果表明,NAT10高表达与肝癌患者临床预后不良因素相关,NAT10高表达患者更易于进展到晚期。基因集富集分析(gene set enrichment analysis,GSEA)结果显示,NAT10高表达样本中,异生物质代谢、凝血、脂肪酸代谢等相关基因特征均有差异富集。蛋白互作分析结果显示,NAT10可能与IGF2、SST、MUC2、CHGA、AGR2等基因存在相互作用。结论NAT10在肝癌中高表达,且表达水平与肝癌的临床特征及患者生存率存在相关性。NAT10可能是一种潜在的肝癌预后生物学标志物。
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