目的探讨基于无创左室压力-应变环(LV-PSL)技术评估急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术前、后的心肌做功情况及左室重构的临床价值。方法选择70例AMI患者(冠心病组)及同期体检的50例健康成人(对照组)。比较对照组和冠心病组术前、术后7 d检查常规超声心动图指标、左室整体纵向应变(GLS)和左室心肌做功指标[整体做功指数(GWI)、整体做功效率(GWE)、整体有用功(GCW)、整体无用功(GWW)]的差异。冠心病组患者进一步根据冠脉造影结果分为冠心病单支组34例和冠心病多支组36例,对比两组上述指标的差异。分析左室心肌做功指标与GLS、常规超声心动图指标的相关性。结果冠心病组术前、术后7d左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)、GWW均高于对照组,左室射血分数(LVEF)、GWI、GWE、GCW、GLS均低于对照组,差异均有统计学意义(P<0.05)。冠心病组术后7 d LVESV、LVEDV、GWW均低于术前,LVEF、GWI、GWE、GCW、GLS均高于术前,差异均有统计学意义(P<0.05)。冠心病多支组术前及术后7 d LVESV、LVEDV、GWW均高于冠心病单支组,LVEF、GWI、GWE、GCW、GLS均低于冠心病单支组,差异均有统计学意义(P<0.05)。相关性分析显示,GWW与GLS、LVEF均呈负相关,GWE、GCW、GWI与GLS、LVEF均呈正相关(P<0.001)。结论LV-PSL技术在评估AMI患者PCI术前、后左心功能及左室重构方面具有较好的应用价值,为临床急性心肌梗死患者经皮冠状动脉介入术术后提供了一种无创、有效的评估新方法。
保留比率肺功能减损(preserved ratio impaired spirometry, PRISm)定义为在吸入支气管扩张剂后,FEV1/FVC ≥ 0.7,FEV1% Preserved ratio impaired spirometry (PRISm) is a heterogeneous lung disease, defined by after bronchodilat...
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保留比率肺功能减损(preserved ratio impaired spirometry, PRISm)定义为在吸入支气管扩张剂后,FEV1/FVC ≥ 0.7,FEV1% Preserved ratio impaired spirometry (PRISm) is a heterogeneous lung disease, defined by after bronchodilator inhalation a forced expiratory volume in one second (FEV1) that is less than 80% of the predicted value, whilst maintaining FEV1/forced vital capacity (FVC) ≥ 0.7. In recent years, although the prevalence of PRISm in the population has been confirmed by some studies, in-depth discussion and research in related fields are still insufficient. Previous studies have found that PRISm population can be caused by a variety of risk factors. And compared with those with normal lung function, the risk of progression to the COPD, the risk of cardiovascular-related mortality and all-cause mortality is significantly increased. Without timely intervention, it may gradually deteriorate to COPD. So it is very important to detect and prevent PRISm early. This review encapsulates research pertaining to PRISm, spanning its incidence, risk factors, disease characteristics, associated diseases, prognosis and treatment, aiming to understand PRISm comprehensively, and hope to provide more accurate condition assessment for PRISm patients, and promote the comprehensive rehabilitation and health management of patients.
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