Background: Motivation: Containing about 22 nucleotides, a microRNA (abbrevi-ated miRNA) is a small non-coding RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene *** human genome ...
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Background: Motivation: Containing about 22 nucleotides, a microRNA (abbrevi-ated miRNA) is a small non-coding RNA molecule, functioning in transcriptional and post-transcriptional regulation of gene *** human genome may encode over 1000 *** poorly characterized, miRNAs are widely deemed as important regulators of biological *** expression of miRNAs has been observed in many cancers and other disease states, indicating they are deeply implicated with these diseases, particularly in ***, it is important for both basic research and miRNA-based therapy to discriminate the real pre-miRNAs from the false ones (such as hairpin sequences with similar stem-loops).Particularly, with the avalanche of RNA sequences generated in the postgenomic age, it is highly desired to develop computational sequence-based methods in this regard.
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