Classic pharmacokinetics based on the detection of drug plasma concentration often seems difficult to evaluate the efficacy because of the mismatch of pharmacokinetics and ***-third of drug targets are located in cell...
详细信息
Classic pharmacokinetics based on the detection of drug plasma concentration often seems difficult to evaluate the efficacy because of the mismatch of pharmacokinetics and ***-third of drug targets are located in cells or subcellular *** multiple physiologic barriers and microenvironment can directly affect the intracellular drug metabolism and disposition and thus the concentration around the *** is a pressing need for pharmacokinetics to go deep into the cellular or subcellular *** cell models which are more close to pathophysiological conditions should be considered as the objects of study,and then establish the systematic theory and technology of drug metabolism and pharmacokinetics on the targeted cells or subcellular organelles,which can descript the dynamic process of drug metabolism in the target *** will realize the prediction from in vitro to in vivo.A visualized,detectable and quantifiable system on cellular/subcellular level will be established to clarify the dynamic change of drugs and *** on the construction of tumor high bionic in vitro three-dimensional cell model,the process of metabolism,pharmacokinetics and pharmacodynamics will be comprehensively studied to clarify the characteristics in different pathophysiological conditions and the regulatory *** the systematic evaluation from micro to macro,from cell and tissue to animal or human body,can provide a new theory and technology system for drug screening,preparation design and clinical rational administration.
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