目的:分析中性粒细胞百分比/白蛋白比值(NPAR)对阵发性房颤(PAF)患者射频消融术(RFCA)后复发的预测价值。方法:回顾性纳入2022年7月至2023年7月期间首次接受RFCA治疗的142例PAF患者,术后持续随访1年并根据房颤复发情况把研究人群分为复发组(33例)和未复发组(109例)。比较两组人群的临床资料,应用多因素logistic回归分析PAF患者RFCA术后房颤复发的危险因素,绘制受试者工作特征(ROC)曲线,评价NPAR对PAF患者RFCA术后房颤复发的预测价值。结果:与未复发组相比,复发组人群房颤病程较长、LVEF水平降低、LAD水平升高、白蛋白水平偏低、NPAR水平更高,组间差异具有统计学意义(P Objective: To evaluate the predictive value of neutrophil percentage/albumin ratio (NPAR) in patients with paroxysmal atrial fibrillation (PAF) after radiofrequency ablation (RFCA). Methods: 142 patients with PAF treated from July 2022 to July 2023 were retrospectively included, all of whom received RFCA. They were followed up for 1 year after surgery and were divided into a relapse group (33 cases) and a non-recurrence group (109 cases) according to the recurrence of atrial fibrillation. Clinical data of the two groups were collected, and the NPAR ratio was calculated. Multivariate logistic regression was used to analyze the risk factors of recurrent atrial fibrillation in PAF patients after RFCA. The receiver operating characteristic (ROC) curve was drawn to analyze the value of the NPAR ratio in predicting atrial fibrillation recurrence in PAF patients after RFCA. Results: The duration of atrial fibrillation in the relapsed group was longer than that in the non-relapsed group, the level of albumin was lower than that in the non-relapsed group, and the ratio of NPAR was higher than that in the non-relapsed group (P < 0.05). The results of multivariate logistic regression analysis showed: The duration of atrial fibrillation was prolonged (OR = 4.792, 95% CI = 1.972~11.645), the albumin level was decreased (OR = 8.117, 95% CI = 1.549~42.530), and the NPAR ratio was increased (OR = 6.309, 95% CI = 1.474~27.013) were risk factors for recurrence of atrial fibrillation after RFCA in PAF patients (P < 0.05). ROC curve results showed that the AUC of NPAR ratio predicting atrial fibrillation recurrence after RFCA in PAF patients was 0.847 (95% CI = 0.766~0.927, P <
苍术作为我国一味传统中药材,具有燥湿健脾、祛风散寒、辟秽化浊、明目等功效,具有促进胃肠蠕动、保护胃黏膜、抗炎、利尿等药理作用,且苍术常与白术、黄柏、厚朴等药物以药对形式应用于临床。本文整理了近年来中国知网、万方、中药系统药理学分析平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)、PubMed资料库中围绕苍术及其药对药理作用、临床应用及相关网络药理学。本文对苍术及其药对的研究现状及进展进行综述,并对其作用机制进行探讨,为揭示苍术药对应用规律、配伍理论方面提供依据和新的思路。
目的探讨三酰甘油葡萄糖乘积(triglyceride-glucose index,TyG)指数和血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)与老年冠心病(coronary heart disease,CHD)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者冠状动脉...
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目的探讨三酰甘油葡萄糖乘积(triglyceride-glucose index,TyG)指数和血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)与老年冠心病(coronary heart disease,CHD)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者冠状动脉正性重构的关系。方法按照住院先后顺序选取2022年1月至2023年6月河南科技大学第一附属医院心血管内科收治的老年CHD合并T2DM患者120例,根据重构指数分为正性重构组47例和非正性重构组73例。比较2组临床资料;采用多因素logistic回归分析冠状动脉正性重构的危险因素;采用Spearman相关性分析TyG和AIP与冠状动脉正性重构的相关性;采用ROC曲线分析TyG和AIP对冠状动脉正性重构的预测价值。结果正性重构组吸烟、三酰甘油、糖化血红蛋白、TyG、AIP显著高于非正性重构组,高密度脂蛋白胆固醇、血钙水平显著低于非正性重构组(P<0.05,P<0.01)。单因素logistic回归分析显示,吸烟、三酰甘油、高密度脂蛋白胆固醇、糖化血红蛋白、血钙、TyG、AIP是老年CHD合并T2DM患者冠状动脉正性重构的危险因素(P<0.05,P<0.01)。多因素logistic回归分析显示,TyG(OR=7.253,95%CI:2.458~13.364,P=0.035)、AIP(OR=6.017,95%CI:2.205~12.025,P=0.030)是老年CHD合并T2DM患者冠状动脉正性重构的独立危险因素(P<0.05)。TyG、AIP预测老年CHD合并T2DM患者冠状动脉正性重构的曲线下面积分别为0.783、0.766,联合预测老年CHD合并T2DM患者冠状动脉正性重构的曲线下面积为0.868,显著优于单独预测(P<0.05)。结论TyG和AIP与老年CHD合并T2DM患者冠状动脉正性重构密切相关,可作为预测冠状动脉正性重构的有效指标,对临床早期识别高危患者及制定个体化干预策略具有重要意义。
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