Objective To study the feasibility of the crossover trial design and the minimal imbalance index random distribution method in the clinical small-sample-size randomized controlled trial(RCT) research of thalamic pai...
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Objective To study the feasibility of the crossover trial design and the minimal imbalance index random distribution method in the clinical small-sample-size randomized controlled trial(RCT) research of thalamic pain treated with acupuncture under the guidance of evidence-based medicine(EBM).Methods The crossover trial design was *** cases with the definite diagnosis were randomized into a program-I group(6 cases,treated with acupuncture before western medicine) and a program-II group(5 cases,treated with western medicine before acupuncture) according to the minimal imbalance index *** the statistical analysis,the groups were named as an acupuncture group and a western medicine group separately,11 cases in each *** was applied to Xìmén(郄门 PC 4),Yīnxì(阴郄 HT 6),Xuèhǎi(血海 SP 10),*** the control treatment,Carbamazepine was prescribed for oral *** the duration of treatment or the wash-out period was 10 *** visual analogue scale(VAS) was adopted for the efficacy *** The total effective was 100.0%(11/11) after treatment in either *** remarkably effective rates were 63.6%(7/11) and 36.4%(4/11) in the acupuncture group and the western medicine group separately,without statistically significant difference in *** The crossover trial design and the minimal imbalance index distribution method can accomplish RCT of the clinical acupuncture and moxibustion research with the small sample size *** can provide the high-quality evidences for clinical acupuncture *** therapy can achieve the same therapeutic effect as Carbamazepine,the common western medicine,and the efficacy of it is potentially superior to that of western medicine.
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