目的分析安罗替尼所致心血管不良反应的发生规律和临床特点,为临床安全用药提供参考。方法检索2018年8月—2022年5月万方、中国知网、维普、PubMed、Web of Science、Embase数据库中安罗替尼致心血管不良反应(ADR)的个案报道,筛选后进...
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目的分析安罗替尼所致心血管不良反应的发生规律和临床特点,为临床安全用药提供参考。方法检索2018年8月—2022年5月万方、中国知网、维普、PubMed、Web of Science、Embase数据库中安罗替尼致心血管不良反应(ADR)的个案报道,筛选后进行统计分析。结果共收集20篇个案报道,涉及20例患者,其中男性9例(45.0%),女性11例(55.0%)。患者年龄集中在50~69岁,ADR多发生在用药后7~90 d,以高血压最为常见,主动脉夹层、可逆性后部白质脑病综合征、高血压性视网膜病变等ADR未在说明书中提及。结论临床使用安罗替尼应加强监测,警惕其心血管ADR,尤其注重防治高血压,及时识别并发症,确保临床用药安全。
背景 肠道菌群与精神分裂症之间的相关机制尚不清楚。探究急性组、缓解组精神分裂症患者肠道菌群丰度差异,以及与临床症状的相关性。方法 本研究共纳入124例参与者,收集一般资料及粪便,采用16S rRNA基因测序分析肠道微生物,由精神科医生使用阳性与阴性症状量表(PANSS)评定患者症状得分。结果 三组间一般资料无明显差异,急性组、缓解组在病程、氯丙嗪当量上无明显差异。急性组PANSS各因子评分和总分均高于缓解组(P<0.05)。16SrRNA结果示三组之间在属水平上有9种肠道菌群组成发生改变。相关性分析示,急性组存在4个菌属与临床症状存在相关性,缓解组中仅梭状芽孢杆菌属与症状呈负相关。结论 不同疾病阶段精神分裂症患者肠道菌群组成存在差异,且与临床症状相关。
关键词:精神分裂症;肠道菌群;16S rRNA测序
中图分类号: R593.2
Study on the correlation between intestinal flora and clinical symptoms of schizophrenic patients at different disease stages
SHI Li 1, 2, 3 LI Jingwei 1, 2, 3 ZHANG Xulai 1, 2, 3, 4 (corresponding author)
1. Affiliated Psychological Hospital of Anhui Medical University, Anhui Hefei 230022
2. Anhui Provincial Mental Health Center, Anhui Hefei 230022
3. Hefei Fourth People's Hospital, Anhui Hefei 230022
4. Anhui Provincial Clinical Medical Research Center for Mental and Psychological Diseases, Anhui Hefei 230022
Abstract: Background The relevant mechanism between intestinal flora and schizophrenia is still unclear. Objective To explore the difference of intestinal microflora abundance between acute and remission schizophrenia patients and its correlation with clinical symptoms. Methods A total of 124 participants were included in this study. General data and faeces were collected. 16S rRNA gene sequencing was used to analyze intestinal microorganisms. Psychiatrists used the Positive and Negative Symptom Scale (PANSS) to evaluate the symptoms of patients. Results (1) There was no significant difference in the general data among the three groups. There was no significant difference in the course of disease and chlorpromazine equivalent between the acute group and the remission group. The scores of all factors and total scores of PANSS in acute group were higher than those in remission group (P<0.05). 16SrRNA results showed that the composition of 9 intestinal microflora changed at the genus level among the three groups. Correlation analysis showed that there were 4 genera of bacteria in the acute grou
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