Objective To analyze the influencing factors on the occurrence of anxiety and depression among secondary school students in Shanxi Province in 2023 based on the random forest algorithm and to construct a prediction mo...
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Objective To analyze the influencing factors on the occurrence of anxiety and depression among secondary school students in Shanxi Province in 2023 based on the random forest algorithm and to construct a prediction model to provide a scientific basis for preventing and controlling the occurrence of negative emotions such as anxiety and depression among secondary school students. Methods In September 2023, 104 826 secondary school students in 11 cities of Shanxi Province were selected by stratified random whole-cluster sampling method for questionnaire survey, and the Generalized Anxiety Scale(GAD-7) and the Center for Streamlined Depression Scale(CES-D) were used to investigate anxiety and depression. Epidata was used for database establishment, chi-square test was used for between-group comparisons, logistic regression was used for influencing factor analysis, and Python 3.7 was used to establish a random forest prediction model and rank the importance of each variable. Results The detection rates of anxiety and depression among secondary school students in Shanxi Province in 2023 were 33.26% and 23.72%, respectively, and were higher for girls than for boys, and higher for students in general and vocational high schools than for junior high school students. The results of multifactorial regression analysis showed that female students(OR: 1.846、1.655,95%CI: 1.794-1.901、1.602-1.710), high school(OR: 2.019、1.670,95%CI: 1.956-2.083、1.612-1.731), vocational high school(OR: 1.167、1.356,95%CI: 1.085-1.254、1.254-1.466), non-conventional family(OR: 1.105、1.248,95%CI: 1.072-1.140、1.206-1.292), living in school(OR: 1.102、1.117,95%CI: 1.070-1.136、1.080-1.155), eating fried food ≥1 time/day(OR: 1.296、1.375,95%CI: 1.227-1.369、1.297-1.457), being seriously injured(OR: 1.636、1.688,95%CI: 1.524-1.755、1.569-1.816), being bullied in school(OR: 2.315、3.411,95%CI: 2.150-2.492、3.165-3.677), being scolded by parents(OR: 2.881、3.191,95%CI: 2.766-3.001、3.059-3.328), smoking(OR: 1.344、1.435
目的探讨乙型肝炎(乙肝)表面抗原(Hepatitis B surface antigen,HBsAg)阳性母亲乙肝病毒(Hepatitis B virus,HBV)DNA载量和婴儿出生时线粒体抗病毒信号蛋白(Mitochondrial antiviral signaling protein,MAVS)信号通路对婴儿接种乙肝疫苗...
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目的探讨乙型肝炎(乙肝)表面抗原(Hepatitis B surface antigen,HBsAg)阳性母亲乙肝病毒(Hepatitis B virus,HBV)DNA载量和婴儿出生时线粒体抗病毒信号蛋白(Mitochondrial antiviral signaling protein,MAVS)信号通路对婴儿接种乙肝疫苗(Hepatitis B vaccine,HepB)无/弱应答的影响。方法选择2019年11月至2022年6月太原市某医院分娩的HBsAg阳性母亲及其婴儿,检测母亲HBV DNA载量、婴儿出生时脐血免疫细胞比例和MAVS信号通路蛋白表达百分比、婴儿乙肝免疫球蛋白和HepB全程接种后1-2月血清乙肝表面抗体(Hepatitis B surface antibody,HBsAb)。采用多因素Logistic回归模型分析HBV DNA和MAVS信号通路对婴儿接种HepB无/弱应答的影响。结果婴儿HepB全程接种后无/弱应答率为14.38%(22/153)。多因素Logistic回归分析显示,母亲HBV DNA载量高、脐血MAVS、pIRF3和pNF-κB蛋白表达百分比低、脐血浆细胞比例低的婴儿HepB无/弱应答率高[OR(95%CI):3.94(1.11-14.00)、1.44(1.15-1.73)、4.17(1.16-14.96)、1.94(1.38-2.51)、3.97(1.14-13.79)]。结论HBsAg阳性母亲HBV DNA载量和婴儿出生时MAVS信号通路显著影响婴儿接种HepB的免疫应答;相关检测有助于识别HepB无/弱应答高危人群。
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