目的:系统梳理2003~2023年高血压痰瘀互结证领域的研究动态及前沿热点,揭示其学术发展脉络。方法:以中国知网(CNKI)、万方(Wanfang)、维普(VIP)数据库中2003年1月1日至2023年12月31日收录的高血压痰瘀互结证相关文献为研究对象,通过文献计量学方法对符合纳入标准的355篇文献进行定量分析,运用可视化技术对发文量时序分布、作者合作网络、机构协作关系及关键词共现网络进行图谱解析。结果:1) 年度发文量呈阶梯式增长,2010年后进入快速发展期(年均增长率达15.6%);2) 研究力量分布呈现核心作者引领与机构间协作不足的双重特征:韩学杰团队(累计发文23篇)及中国中医科学院中医临床基础医学研究所(发文量占比18.3%)为领域内主要贡献者,但73.5%的作者为独立发文,跨机构合作率不足10%;3) 关键词聚类分析显示,研究热点聚焦于四大主题:痰瘀互结证病理机制(如血脂异常、一氧化氮/内皮素失衡)、中医干预策略(化痰祛瘀复方、针药并用)、临床疗效评价(证候积分改善率)及生物标志物探索(炎症因子CRP、TNF-α)。结论:我国学者在高血压痰瘀互结证领域开展了积极且富有成效的研究,整体发展态势良好,研究广度和深度持续拓展。然而,目前的研究多集中于基础理论和临床实践层面,建议未来进一步深入分子水平和细胞机制的研究,并加强多机构间的合作与交流,以推动该领域的创新发展。Objective: To systematically analyze the research trends and hotspots in the field of hypertension with phlegm and stasis interconnection from 2003 to 2023, and to reveal its academic development. Methods: Taking the literature related to hypertension phlegm and stasis syndrome included in the databases of China National Knowledge Infrastructure (CNKI), Wanfang and VIP from January 1, 2003 to December 31, 2023 as the research object, 355 pieces of literature meeting the inclusion criteria were quantitatively analyzed by bibliometric methods, and visualization techniques were used to analyze the temporal distribution of the number of articles, the authors’ collaborative network, Institutional Collaboration Network and Keyword Co-occurrence Network. Results: 1) The annual number of published papers increased step by step, and entered a period of rapid development after 2010 (with an average annual growth rate of 15.6%). 2) The distribution of research strength showed the dual characteristics of core author leadership and insufficient inter-agency collaboration: Han Xuejie’s team (23 articles in total) and the Institute of Clinical Basic Medicine of Chinese Academy of Chinese Medical Sciences (18.3 % of the total) were the main contributors in the field, but 73.5% of the authors were independent, and the cross-agency cooperation rate was less than 10%. 3) Keywords cluster analysis sh
目的:本文总结1例顽固性偏头痛患者行耳穴三序疗法治疗的护理经验。方法:1名头痛20余年,加重2周患者,就诊时,PSQI评分18分,SAS评分68分,VAS评分5分,应用耳穴三序疗法即耳部刮痧、耳轮放血、耳穴贴压进行治疗,观察其疗效。结果:患者经10次治疗后自觉头痛、失眠及焦虑症状痊愈,PSQI评分9分,SAS评分49分,VAS评分0分。结论:通过中医适宜护理技术耳穴疗法,治疗顽固性偏头痛取得显著疗效,彰显耳穴疗法简便验廉的优势。Objective: To summarize the nursing experience of a patient with intractable migraine treated with three sequence therapy of auricular point. Methods: A patient with headache for more than 20 years and aggravated for 2 weeks was treated with PSQI score of 18, SAS score of 68 and VAS score of 5. The three sequence therapy of auricular point, namely ear gua Sha, earring bleeding and auricular point sticking, was used to observe the curative effect. Results: After 10 treatments, the patient felt that the symptoms of headache, insomnia and anxiety were cured, PSQI score was 9, SAS score was 49, VAS score was 0. Conclusion: Through the appropriate nursing technique of traditional Chinese medicine, auricular acupoint therapy has achieved remarkable effect in the treatment of intractable migraine, demonstrating the advantages of auricular acupoint therapy.
目的对维立西呱治疗射血分数降低心力衰竭(HFrEF)的有效性、安全性和经济性进行快速卫生技术评估,明确该药在HFrEF治疗中的价值。方法系统检索国内外卫生技术评估机构官方网站以及PubMed、EMBASE、The Cochrane Library和University of ...
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目的对维立西呱治疗射血分数降低心力衰竭(HFrEF)的有效性、安全性和经济性进行快速卫生技术评估,明确该药在HFrEF治疗中的价值。方法系统检索国内外卫生技术评估机构官方网站以及PubMed、EMBASE、The Cochrane Library和University of York’s Centre for Reviews and Dissemination、中国学术期刊全文数据库(http://***)、万方、中国生物医学文献数据库,筛选出符合标准的HTA报告、系统综述、Meta分析、临床研究等,2~4名研究人员独立进行文献筛选、数据提取和质量评价后,对结果进行描述性分析。结果最终纳入HTA报告2篇,指南6篇,随机对照临床试验(RCT)2篇,经济学研究4篇。标准优化治疗上加用维立西呱可能可以降低年龄<75岁,近期经历心衰恶化且经静脉治疗后病情稳定的射血分数降低的症状性慢性心衰患者的心衰住院风险。现有证据未显示维立西呱可改善全因死亡、心血管死亡、生活质量;未显示增加总不良事件发生率、严重不良事件发生率、因不良事件而终止治疗率、高钾血症和肾功能异常发生率。维立西呱可能带来更高的血液和淋巴系统不良事件风险,主要表现为贫血;是否增加低血压风险尚不明确。国内经济学研究均完成于维立西呱价格调整前,结果显示维立西呱不具备成本效益,价格调整后的经济性尚待研究。结论维立西呱可能可以减少特定心衰人群的住院风险;安全性可接受,使用过程中需注意贫血、低血压;价格调整后的经济性待进一步研究。
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