脓毒症是一种由感染引发的全身性炎症反应,严重时可导致多器官功能障碍,其中急性肾损伤(AKI)是常见的并发症之一。文章旨在通过CiteSpace 6.1.R3软件,对2004年至2024年间关于脓毒症致肾损伤的国外研究文献进行计量学分析。通过检索Web of Science、Pubmed数据库获取文献数据,运用文献计量学方法,从文献的发表数量、发文国家及地区、作者、关键词聚类、关键词突现等方面进行分析,以揭示该领域的研究现状、热点及发展趋势,为脓毒症致肾损伤的进一步研究提供参考。Sepsis is a systemic inflammatory response triggered by infection, which can lead to multi-organ dysfunction in severe cases, among which Acute Kidney Injury (AKI) is one of the common complications. The purpose of this paper is to conduct an econometric analysis of foreign research literature on sepsis-induced kidney injury between 2004 and 2024 by CiteSpace 6.1.R3 software, obtaining literature data by searching Web of Science and Pubmed databases, and applying bibliometric methods to analyze the literature in terms of the number of publications, country and region, authors, keyword clustering, keyword emergence, etc. This analysis aims to reveal the current status, hotspots, and development trends of this field and to provide a reference for further research on renal injury caused by sepsis.
目的探讨血清淀粉样蛋白A(SAA)、中性粒细胞与淋巴细胞比值(NLR)对多学科救治重度子痫前期患者不良妊娠结局的预测价值。方法回顾性纳入2014年10月至2022年7月收住杭州市第一人民医院ICU多学科联合救治的重度子痫前期患者105例作为研究对象,根据患者妊娠结局分为不良妊娠结局组(62例)和非不良妊娠结局组(43例)。收集所有患者入院后24 h内的SAA、NLR等化验指标及相关临床资料。比较两组患者的一般临床资料,利用Logistic多因素回归分析寻找影响多学科救治重度子痫前期患者不良妊娠结局的危险因素,以受试者工作特征(receiver operating characteristic,ROC)曲线评估SAA、NLR对多学科救治重度子痫前期患者不良妊娠结局的预测价值。结果不良妊娠结局组患者ICU住院时间[4.00(3.00,5.00)vs.3.00(3.00,4.00),P=0.022]、APACHEⅡ(acute physiology and chronic health evaluationⅡ)评分[9.00(7.00,11.25)vs.7.00(5.00,9.00),P=0.002]、白细胞计数[(12.29±4.25)vs.(10.41±4.00),P=0.025]、SAA[37.85(11.00,72.83)vs.9.00(8.00,20.70),P<0.001]、NLR[7.95(5.22,12.37)vs.5.20(3.25,8.77),P=0.002]均高于非不良妊娠结局组,妊娠周数[30.00(26.75,31.00)vs.33.00(32.00,35.00),P<0.001]、直接胆红素[2.10(1.50,2.50)vs.2.20(1.90,4.60),P=0.019]、碱性磷酸酶[99.00(74.00,124.25)vs.133.00(95.00,188.00),P<0.001]水平小于非不良妊娠结局组,差异有统计学意义(P<0.05)。Logistic多因素回归分析结果显示,妊娠周数越早(OR=0.564,95%CI:0.408~0.780,P<0.001),SAA(OR=1.028,95%CI:1.002~1.055,P=0.036)、APACHEⅡ评分(OR=1.282,95%CI:1.048~1.569,P=0.016)越高,重度子痫前期患者发生不良妊娠结局可能性越大。SAA、NLR及SAA、NLR与APACHEⅡ评分联合的ROC曲线下的面积(area under curve,AUC)分别为0.770、0.678、0.844,SAA、NLR与APACHEⅡ评分联合预测效能高于单一预测(P<0.05)。结论SAA、NLR对多学科救治重度子痫前期患者不良妊娠结局具有良好的预测效能,SAA、NLR联合APACHEⅡ评分预测效能高于单一指标预测。
暂无评论