Cadmium(Cd)is an environmental and industrial pollutant that induces a broad spectrum of toxicological effects,influences a variety of human organs,and is associated with poor semen quality and male *** evidence demon...
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Cadmium(Cd)is an environmental and industrial pollutant that induces a broad spectrum of toxicological effects,influences a variety of human organs,and is associated with poor semen quality and male *** evidence demonstrates that Cd induces testicular germ cell apoptosis in rodent ***,the specific effect of Cd exposure on autophagy in sperm cells is poorly *** the present study,our data has shown that autophagy was significantly elevated in mouse spermatocyte cell line(GC-2spd)exposed to ***,there was a reduction in rapamycin(RAP)-mediated *** addition,Cd exposure reduced cell viability,which is an effect that could be significantly inhibited by RAP *** and cell death were elevated in Cd-exposed cells in response to 3-methyladenine(3-MA),an inhibitor of *** results indicate that autophagy appears to serve a positive function in reducing Cd-induced ***,our data suggest that autophagy appears to act as a defense/survival mechanism against Cd cytotoxicity in GC-2spd cells.
Spinocerebellar ataxia 3(SCA3),also known as Machado-Joseph disease(MJD),is the most common dominant inherited ataxia *** caused by an unstable CAG trinucleotide expansion mutation within the SCA3 gene resulting in an...
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Spinocerebellar ataxia 3(SCA3),also known as Machado-Joseph disease(MJD),is the most common dominant inherited ataxia *** caused by an unstable CAG trinucleotide expansion mutation within the SCA3 gene resulting in an expanded polyglutamine tract within the ataxin-3 protein and is a neurodegenerative disorder incurable to *** the present study,we used the episomal reprogramming assay to produce SCA3 iPS from a female patient's skin *** patientderived iPS cells express the same characteristics with human embryo stem cells,and can be differentiated into neural cells,which have the normal action potential,and no changes in CAG repeat length were detected during the time course for at least35 passages as iPSCs,up to 3 passages as neural stem cells and 4 weeks of neural ***,we demonstrated that the neural differentiation is accompany with the *** conclusion,the patient-specific iPS cells is a good model of SCA3 and neural differentiation is accompany with the autophagy.
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