目的对比研究伴有低度数角膜散光的白内障患者植入散光矫正型人工晶状体和非散光矫正型人工晶状体的临床疗效。方法回顾性队列研究。收集2021年1月至2021年7月于沈阳爱尔眼视光医院确诊为低度数规则性角膜散光(0.75D～1.5D)的年龄相关性白内障81例(82眼)行白内障超声乳化术的患者,分别植入散光矫正型人工晶状体(AcrySof IQ T2/T3 Toric IOL)(Toric组,n=48眼)及非散光矫正型人工晶状体(AcrySof IQ IOL)(IQ组,n=34眼)。
血脑屏障(blood brain barrier, BBB)是存在于外周血液和脑组织之间的结构,保护大脑免受内源性及外源性毒素和病原体的侵害,从而维持脑内环境稳定。在中枢神经系统疾病中,血脑屏障的破坏将进一步加剧疾病的进展。研究表明血小板源性生长因子(platelet-derived growth factor, PDGF)在血脑屏障的形成及功能维持中发挥重要作用,本文总结了PDGF及其受体在生理及病理情况下对血脑屏障的影响,初步探讨PDGF在中枢神经系统疾病中的治疗可能性,并对当前靶向PDGF及其受体的治疗手段进行简要综述。The blood brain barrier (BBB) is a structure that exists between peripheral blood and brain tissue, protecting the brain from endogenous and exogenous toxins and pathogens, thereby maintaining the stability of the brain internal environment. In central nervous system diseases, the disruption of BBB further exacerbates disease progression. Compelling data indicates that platelet-derived growth factor (PDGF) plays an important role in the maintenance and formation of BBB. This article summarizes the effects of PDGFs and their receptors on the integrity of BBB under physiological and pathological conditions. Finally, we briefly summarize the potential therapeutic strategy of PDGFs in central nervous system diseases, and review the current therapeutic methods targeting PDGFR.
暂无评论