We investigated the expression of procollagen typeⅠ,matrix metalloproteinase 1(MMP1)and tissue Inhibitor of metalloproteinase 1(TIMP-1)by immunohistochemistry in human patellar tendinosis tissues and healthy patellar...
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We investigated the expression of procollagen typeⅠ,matrix metalloproteinase 1(MMP1)and tissue Inhibitor of metalloproteinase 1(TIMP-1)by immunohistochemistry in human patellar tendinosis tissues and healthy patellar *** situ gelatin zymography was used to detect collagenolytic *** production of MMP1,TIMP1 and gelatinolytic activities was compared in cell cultures from both tendinosis samples and *** tissues and cultures had increased expression level of MMP1 and decreased expression level of TIMP1,a condition favoring collagen *** findings from in situ gelatin zymography and gel zymography also indicated elevated gelatinolytic activities in tendinosis tissues and *** is a striking feature in patellar tendinosis.
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