目的:通过心肺运动试验(cardiopulmonary exercise testing,CPET)研究恢复初期肺血栓栓塞症(pulmonary thromboembolism,PE)患者的摄氧效率(oxygen uptake efficiency,OUE)与运动耐力的相关性。方法:对42例恢复初期的肺栓塞患者(PE组)和42例同年龄段健康志愿者(对照组)进行CPET和常规肺功能检测(pulmonary function test,PFT),并测定相关的功能学指标。结果:CPET测定结果显示PE组的用力肺活量占预计值百分比(forced vital capacity as a percentage of predicted value,FVC%pred)、1秒钟用力呼气容积占预计值百分比(forced expiratory volume in 1 second as a percentage of predicted value,FEV1%pred)、一氧化碳弥散量占预计值百分比(diffusion capacity for carbon monoxide a sa percentage of predicted value,DLco%pred)及肺总量占预计值百分比(total lung capacity as a percentage of predicted value,TLC%pred)均显著低于对照组[(81.03±19.82)%vs(102.36±11.14)%,(78.91±21.18)%vs(98.62±11.24)%,(83.58±21.80)%vs(108.92±23.58)%及(91.01±18.12)%vs(103.27±7.82)%,均P<0.05]。PE组的峰值摄氧量(peak oxygen uptake,peakVO_2)、摄氧效率斜率(oxygen uptake efficiency slope,OUES)、摄氧效率平台(oxygen uptake efficiency plateau,OUEP)和无氧阈摄氧效率(oxygen uptake efficiency at the anaerobic threshold,OUE@AT)均显著低于健康对照组[(1077.33±107.32)mL/minvs(1637.55±61.39)mL/min,(1.43±0.47)vs(2.03±0.44)(L/min)/lg(L/min),(30.25±5.21)mL/Lvs(35.04±4.11)mL/L,(29.27±5.74)mL/Lvs(34.01±4.18)mL/L,均P<0.01]。PE组的OUES,OUEP和OUE@AT与peakVO2均呈正相关(r=0.789,r=0.676,r=0.655;均P<0.001)。结论:恢复期PE患者的OUE显著低于健康正常人,且与运动耐力呈显著相关。
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