Itch is one of the least well understood of all the somatic *** perception and processing rely on dedicated sensory neural *** particular, the neural circuits that underlie this sensation are poorly *** investigated t...
详细信息
Itch is one of the least well understood of all the somatic *** perception and processing rely on dedicated sensory neural *** particular, the neural circuits that underlie this sensation are poorly *** investigated the contribution of neuropeptides in itch signaling and found by in situ hybridization that the neuropeptide somatostatin(Sst) is colocalized with Nppb, a neuropeptide required for itch *** is an endogenous non-opioid neuropeptide and expressed in a small population of DRG *** is also expressed by many dorsal horn excitatory *** injection of Sst elicits vigorous ***, the neural basis for this effect is unknown and the underlying role of Sst in itch neural circuit is *** we used multiple approaches to examine how itch sensation can be modulated by *** activation of somatostatin-neurons produced robust scratching *** chemogenetics, pharmacology and cell-specific ablation methods, we demonstrate that somatostatin potentiates itch via dorsal horn inhibitory dynorphin *** results reveal, at both molecular and cellular levels, the mechanisms by which somatostatin modulates itch.
暂无评论