目的:探究中药组方化石汤对上尿路结石术后复发的预防作用。方法:随访潍坊市人民医院60例经治疗后结石全部排出的临床痊愈的上尿路结石患者,采用随机单盲对照的方法,验证自拟中药组方化石汤对上尿路结石患者预防的疗效;并应用大鼠草酸钙结石模型加以验证,探究其可能的作用机制。结果:临床研究中两组患者的基本情况的比较:年龄(44.23 ± 2.37岁vs 45.47 ± 2.94岁)、性别(70%:30% vs 63.3%:36.7%)的差异无统计学意义(P > 0.05)。结石复发率(3.3% vs 16.7%)的差异无统计学意义(P > 0.05),尿液生化检测方面,尿PH值(6.4 ± 0.55 vs 5.9 ± 1.14)、尿UA (2.85 ± 0.76 mmol/L vs 3.31 ± 0.95 mmol/L)、尿Ox (0.43 ± 0.32 mmol/L vs 0.61 ± 0.38 mmol/L)的差异存在统计学意义(P 0.05)。尿Mg:空白组与结石组(0.86 ± 0.07 mmol/L vs 0.63 ± 0.06 mmol/L)比较,差异存在显著统计学意义(P 0.05)。大鼠肾指数:结石组较空白组、化石汤组肾脏明显增大(1.04% ± 0.22% vs 0.93% ± 0.12%、0.97% ± 0.21%),但差异均无统计学意义(P > 0.05)。大鼠肾组织Elisa检测指标结果:超氧化物歧化酶(SOD)活力结果:空白组、化石汤组与结石组(128.43 ± 23.76 U/mgprot、98.63 ± 19.36 U/mgprot vs 56.13 ± 12.14 U/mgprot)相比,差异具有显著统计学意义(P Objective: To investigate the preventive effect of the Chinese herbal formula Hua Shi Tang on postoperative recurrence of upper urinary tract stones. Methods: Weifang People’s Hospital followed up 60 clinically cured patients with upper urinary tract stones who had all stones discharged after treatment, and used a randomized single-blind controlled method to verify the efficacy of the self-proposed traditional Chinese medicine formula Hua Shi Tang on the prevention of patients with upper urinary tract stones;and applied the rat calcium oxalate stone model to verify it, and to explore the possible mechanism of its action. Results: There were no significant differences in age (44.23 ± 2.37 years vs 45.47 ± 2.94 years) and gender (70%:30% vs 63.3%:36.7%) between the two groups in the clinical study (P > 0.05). There was no significant difference in stone recurrence rate (3.3% vs 16.7%) (P > 0.05). Among urinary PH (6.4 ± 0.55 vs 5.9 ± 1.14), urinary UA (2.85 ± 0.76 mmol/L vs 3.31 ± 0.95 mmol/L), urinary Ox (0.43 ± 0.32 mmol/L vs 0.61 ± 0.38 mmol/L), the differences were statistically significant (P 0.05). Urinary Mg: There was a statistically significant difference between the blank group and the stone group (0.86 ± 0.07 mmol/L vs 0.63 ± 0.06 mmol/L) (P
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