Animal models are essential for the development of new anti-infectious *** some bacterial infection models have been established in rodents,small primate models are ***,we report on two bacterial infection models esta...
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Animal models are essential for the development of new anti-infectious *** some bacterial infection models have been established in rodents,small primate models are ***,we report on two bacterial infection models established in tree shrew（Tupaia belangeri chinensis）.A burnt skin infection model was induced by dropping 5×106 CFU of Staphylococcus aureus on the surface of a wound after a third degree *** dose of *** caused persistent infection for 7 days and obvious inflammatory response was observed 4 days after inoculation.A Dacron graft infection model,2×106 CFU of Pseudomonas aeruginosa also caused persistent infection for 6 days,with large amounts of pus observed 3 days after *** models were used to evaluate the efficacy of levofloxacin（LEV） and cefoperazone（CPZ）,which reduced the viable bacteria in skin to 4log10 and 5log10 CFU/100 mg tissue,*** number of bacteria in graft was significantly reduced by 4log10 CFU/mL treatment compared to the untreated group（P0.05）.These results suggest that two bacterial infection models were successfully established in tree shrew using *** and *** addition,tree shrew was susceptible to *** and ***,thus making it an ideal bacterial infection animal model for the evaluation of new antimicrobials.
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