PTEN is a candidate tumor suppressor which has sequence homology with dual-specificity phosphatase. PTEN is a multifunctional protein endowed with a phosphatase activity capable of dephosphorylating both tyrosine phos...
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PTEN is a candidate tumor suppressor which has sequence homology with dual-specificity phosphatase. PTEN is a multifunctional protein endowed with a phosphatase activity capable of dephosphorylating both tyrosine phosphate, serine/threonine phosphate residues on proteins and phospholipids of the phosphatidylinositol pathway. PTEN appears to be mutated at considerable frequency in several types of human tumors, including those from brain, breast, endometrium, and prostate. PTEN play an important role in pathogenesis of tumor, tumor cell invasion and metastasis. In this review, we will discuss the chemical structure of PTEN, its phosphatase activity, the ability of affecting signal transduction, and its mutational status in cancer.
The tumor stem cell theory supposed that tumor stem cells are the origin of tumor abnormal proliferation,invasion,metastasis,drug resistance and *** the theory is put forward,it redefines the functions of classic stem...
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The tumor stem cell theory supposed that tumor stem cells are the origin of tumor abnormal proliferation,invasion,metastasis,drug resistance and *** the theory is put forward,it redefines the functions of classic stem cells in *** is a great event for recent studies on glioma initiating cells as brain tumor stem cells were identified and isolated successfully.A lot of evidence from experiments in vivo and in vitro demonstrates that brain tumor stem cells might play an important role in glioma *** this review,we discuss the relationship between tumor stem cells and tumorigenesis,and the research on the correlation between brain tumor stem cells and glioma genesis.
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