A breakthrough has recently been made in the studies on pathogenesis of HIV disease,which result in some new *** strategies for HIV drug and vaccine development are emerging in the impact of these new *** intestinal i...
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A breakthrough has recently been made in the studies on pathogenesis of HIV disease,which result in some new *** strategies for HIV drug and vaccine development are emerging in the impact of these new *** intestinal infection hypothesis proposes that HIV disease can be regarded as some kind of infectious disease of gut immune system as the major HIV infection is located in *** acute catastrophe hypothesis suggests that the subsequent pathological changes are the fallout from a mucosal catastrophe of acute intestinal HIV infection,in which the majority of CD4+ T cells are deleted due to *** general immune overactivation hypothesis proposes that the general immune overactivation is harmful to patient as it increases the cell susceptibility to HIV infection and supportiveness of HIV *** host proteins related to HIV replication can be new targets for HIV drug *** mucosal vaccine strategies,which attempt to induce HIV specific neutralizing antibodies on mucosal surface may be the first choice in development of prophylactic HIV *** of tolerance may be one of the strategies for HIV therapeutic vaccines because HIV disease can be regarded as autoimmune disease caused by HIV infection.
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