Cobra venom factor (CVF), separated from the cobra venoms, is an acidic glucoproteins with anticomplementory activity The combination of CVF with factor B in the blood produces a stable C3 and C5 converterase resultin...
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Cobra venom factor (CVF), separated from the cobra venoms, is an acidic glucoproteins with anticomplementory activity The combination of CVF with factor B in the blood produces a stable C3 and C5 converterase resulting in complement depletion by activating complement continually. There are many studies on it, such as inflammation, autoimmune disease, xenotransplantation, anti-tumor, etc. CVF is also an important tool drug for the study of complement role in the pathophysiological development of diseases.
Study of depression and antidepressant drugs mainly depends on animal models. Twelve animal models of depression related to some sets of validating criteria are reviewed. Of the 12 models, some traditional models (res...
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Study of depression and antidepressant drugs mainly depends on animal models. Twelve animal models of depression related to some sets of validating criteria are reviewed. Of the 12 models, some traditional models (reserpine reversal, amphetamine potentiation) are rejected as they are devoid of selectivity, insufficient to predict antidepressant activity in the compounds tested. The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model. A combination of several models may be the best way to study depression and to screen antidepressant drugs. This combination can be used to detect compounds comparable to those antidepressants possessing clinically established antidepressant activity.
Mycophenolate acid is a novel immunosuppressive drug. Its target of action is the isomerⅡof inosine 5’-monophosphate dehydrogenase(IMPDH). It inhibits de nove purine synthesis and also decreases expression of adhesi...
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Mycophenolate acid is a novel immunosuppressive drug. Its target of action is the isomerⅡof inosine 5’-monophosphate dehydrogenase(IMPDH). It inhibits de nove purine synthesis and also decreases expression of adhesive molecule. It inhibits selectively the proliferation of lymphocyte, so that it has strong immunosuppressive effects on various rejections to allograft or xenograft, and on autoimmune diseases, and has the features of higher potency and lower toxicity.[
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