Background:Sarcopenia, characterized by impaired muscle mass and function, is a common complication in maintenance hemodialysis(MHD). However, research on the mortality of sarcopenia in MHD patients is limited. Object...
Background:Sarcopenia, characterized by impaired muscle mass and function, is a common complication in maintenance hemodialysis(MHD). However, research on the mortality of sarcopenia in MHD patients is limited. Objective: To investigate the impacts of sarcopenia on mortality in MHD patients. Methods: All 143 MHD patients recruited in this cohort study in March 2021 were tested with bioelectrical impedance analysis and grip strength. Demographic data and laboratory indicators were collected. The patients were divided into sarcopenia and non-sarcopenia groups according to the criteria established by the Asian Working Group on Sarcopenia. By following up for 18 months, the survival status was documented. Kaplan-Meier survival curve, multivariate Cox proportional hazard model, and Fine-Gray competing risk model were used to assess the relationship between sarcopenia and all-cause mortality, cardio-cerebrovascular mortality, and infectious disease mortality. Results: The sarcopenia group had older age, higher spKt/V, the ratio of extracellular to intracellular water and IL-6, and lower BMI, serum phosphorus, serum creatinine, serum albumin, serum prealbumin, extracellular water, intracellular water, grip strength, appendicular skeletal muscle index levels and physical activity compared to the non-sarcopenia group, all with statistically significant differences(all P< 0.05). Kaplan Meier curves showed that the overall survival rate of the sarcopenia group was lower than those of the nonsarcopenia group(Log-rank test χ2=15.99, P< 0.001). Multivariable Cox regression analysis and Fine-Gray competing risk model demonstrated that sarcopenia was independently correlated with all-cause mortality and infectious diseases mortality after adjusting for confounding factors(HR= 2.75, 95%CI 1.07-7.10, P= 0.036;SHR= 5.76, 95%CI 1.15-28.96, P= 0.034). Conclusion: There was highly prevalent sarcopenia among this cohort of patients with MHD. Moreover, sarcopenia was an independent predict
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