乳腺癌居女性恶性肿瘤发病率的第1位,人类表皮生长因子受体2 (human epiderma growth factor receptor-2, HER-2)过表达型的患者病情进展迅速,易发生淋巴结、骨骼、脑等多器官转移。本文回顾性分析1例临床分期为T4N1M0的HER-2过表达型乳腺癌患者,新辅助化疗、靶向治疗后行乳腺癌根治术,术后病理分期为ypTisN0M0,后行化疗、靶向及放疗,观察其疗效,并回顾分析相关文献。该患者随诊至今暂无转移复发。Breast cancer ranks the first place in the incidence of female malignant tumors. Patients with HER-2 over-expressing breast cancer progress rapidly, and lymph node, bone, brain and other organs are prone to metastasis. A case of HER-2 over-expressing breast cancer with clinical stage of T4N1M0 was retrospectively analyzed. After neoadjuvant chemotherapy and targeted therapy, modified radical mastectomy was performed. The pathological stage was ypTisN0M0, and then followed by chemotherapy, targeted therapy and radiotherapy. The patient has no metastasis or recurrence.
垂体催乳素腺瘤(prolactin-secreting adenoma, PRLoma)是最常见的功能性垂体腺瘤,约占成人垂体功能性腺瘤的40%,泌乳素微腺瘤较为常见,很少发展为大腺瘤,最大直径大于40 mm的泌乳素巨腺瘤并不常见。本文报道1例43岁男性患者,检查颅脑CT初次发现鼻咽部肿物时显示鼻咽区占位54 mm × 55 mm,已达到泌乳素巨腺瘤标准。本文针对催乳素瘤的诊断、鉴别及治疗策略进行文献回顾。Prolactin-secreting adenoma (PRLoma) is the most prevalent functional pituitary adenoma, accounting for approximately 40% of adult functional pituitary adenomas. Prolactin microadenomas are relatively common and rarely progress into large adenomas. Prolactin giant adenomas with a maximum diameter exceeding 40 mm are infrequent occurrences. In this paper, we present a case study of a 43-year-old male patient diagnosed with a nasopharyngeal mass measuring 54 mm × 55 mm through craniocranial CT scan, which fulfills the criteria for prolactin giant adenoma. This article provides an overview of the literature concerning the diagnosis, differentiation, and treatment of prolactinoma.
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