骨关节炎(Osteoarthritis, OA)是老年人常见的关节疾病,主要临床表现为慢性疼痛、僵硬和功能障碍,其发病机制尚未完全明确。环状RNA (circRNA)是广泛存在于真核细胞中的一种非编码RNA,具有独特的共价闭合环状结构。近年来,研究发现circRNA在OA进展中起着重要作用,主要通过调节细胞外基质的代谢稳态、炎症反应以及软骨细胞的稳态来参与OA。此外,circRNA还通过细胞间外泌体机制、在软骨细胞中作为蛋白质支架以及甲基化修饰等方式影响OA的发生与发展。本文综述了circRNA的生物发生、特性和功能,探讨了circRNA在OA中的重要作用,并探索其在OA发病机制中的潜在应用。circRNA的发现及其在OA中的潜在作用为OA的早期诊断和病因治疗带来了新的希望。Osteoarthritis (OA) is a common joint disease in the elderly, primarily characterized by chronic pain, stiffness, and functional impairment, with its pathogenesis still not fully understood. Circular RNA (circRNA), a type of non-coding RNA widely present in eukaryotic cells, has a unique covalently closed circular structure. In recent years, studies have found that circRNA plays an important role in the progression of OA, mainly by regulating extracellular matrix metabolic homeostasis, inflammatory responses, and chondrocyte homeostasis. Additionally, circRNA influences the occurrence and development of OA through mechanisms such as intercellular exosome communication, serving as protein scaffolds in chondrocytes, and methylation modifications. This article reviews the biogenesis, characteristics, and functions of circRNA, discusses its significant role in OA, and explores its potential application in the pathogenesis of OA. The discovery of circRNA and its potential role in OA offers new hope for the early diagnosis and etiological treatment of OA.
本文报道一例孕中期先兆流产伴多重耐药菌感染患者,通过有效抗感染及保胎治疗,为有生机儿争取到了宝贵的促胎肺成熟时间、更大的出生体重以及更高的存活几率。妊娠期生殖道感染可造成不良妊娠结局的发生,个体化的治疗方案,尤其是药物种类、剂量和治疗周期的选择,对改善妊娠结局十分重要。This paper reports a case of a patient with threatened abortion with a multi-drug-resistant bacteria infection in the second trimester. Through effective anti-infection and fetal protection treatment, it gained valuable lung maturity time, greater birth weight and a higher survival rate for vigorous children. Reproductive tract infection during pregnancy can cause adverse pregnancy outcomes. A personalized treatment plan, especially the choice of drug type, dose and treatment cycle, is very important to improve pregnancy outcomes.
目的:探讨医生助理协助的健康管理模式对孕产妇保健的效果。方法:选取2022年1月至2023年12月在暨南大学附属第一医院门诊产检自愿选择医生助理协助通过线上线下健康管理指导至产后42天的全流程服务的健康管理组孕妇1020人,随机配对选取同期规律产检提供常规保健服务的1020名孕妇作为对照组,比较两组孕妇对孕期知识掌握度及就医满意度,对两组孕妇心境情绪进行评估,对妊娠常见合并症和并发症及分娩结局进行比较。结果:通过加强孕期保健管理后,健康管理组的孕产妇孕期知识掌握度及就医满意度明显高于对照组,健康管理组的孕妇心理疾病及妊娠期并发症发病率低,其中妊娠期糖尿病孕妇的孕期血糖控制良好,且巨大儿、新生儿窒息率低,围产期并发症总发生率低,差异有统计学意义(P Objective: To explore the effectiveness of a health management model assisted by physician assistants for maternal and child health care. Methods: A total of 1020 pregnant women who voluntarily chose to receive a full-process health management service (including both online and offline health guidance) from January 2022 to December 2023 at the outpatient obstetrics clinic of the First Affiliated Hospital of Jinan University were selected as the health management group. Another 1020 pregnant women who received routine prenatal care were randomly selected as the control group. The two groups were compared in terms of knowledge acquisition about pregnancy, satisfaction with healthcare services, mood assessments, common pregnancy-related complications, and delivery outcomes. Results: Enhanced antenatal care management significantly improved pregnancy-related knowledge and satisfaction with medical services among the health management group compared to the control group. The incidence of mental health issues and pregnancy complications was lower in the health management group. Specifically, pregnant women with gestational diabetes in the health management group had better blood glucose control, and the rates of macrosomia and neonatal asphyxia were lower. The overall incidence of perinatal complications was also lower, with statistically significant differences (P < 0.05). Conclusion: The health management model for pregnant women assisted by physician assistants, combining both offline and online services, significantly improved maternal and child health care outcomes and better ensured the safety of mothers and infants. This model is worthy of cli
膝关节置换手术产生的创伤刺激常使患者术后承受着中到重度疼痛,这不仅使患者术后体验不佳,疼痛应激还会加重机体的内环境紊乱,对患者的术后康复产生不利的影响。现在多模式镇痛理念越来越多被应用到术后镇痛中,即将多种不同机制的镇痛药物和镇痛方法进行合理有效的结合,发挥最佳的镇痛效应。布比卡因脂质体作为一种具有稳定性和长效性特点的新型缓释局麻药在术后多模式镇痛中得到越来越多的应用,尤其是应用在膝关节置换术后镇痛。文章综述了布比卡因脂质体应用于膝关节置换手术后镇痛的应用进展情况。The traumatic stimulus produced by knee replacement surgery often causes patients to suffer from moderate to severe pain after surgery, which not only makes the patient’s postoperative experience poor, but also aggravates the internal environmental disorders of the body, which adversely affects the patient’s postoperative recovery. Nowadays, the concept of multimodal analgesia is more and more often applied to postoperative analgesia, which is to reasonably and effectively combine multiple analgesic drugs and analgesic methods with different mechanisms to exert the best analgesic effect. Liposomal bupivacaine, as a new type of sustained-release local anesthetic with stability and long-acting characteristics, has been increasingly used in postoperative multimodal analgesia, especially in postoperative analgesia after knee arthroplasty. This article reviews the progress of liposomal bupivacaine application for postoperative analgesia after knee replacement surgery.
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