妊娠合并急性胰腺炎是一种少见但潜在严重的疾病,甚至可能危及母婴生命。因此及时诊断和有效治疗对改善母婴预后十分重要。胆结石疾病与高甘油三酯血症是妊娠合并急性胰腺炎的常见病因。其中并发症风险最大的是由高甘油三酯血症引起的急性胰腺炎。此种类型胰腺炎的治疗重难点在妊娠期高脂血症的管理。目前国内外尚无指南。本文报道了一例妊娠合并急性胰腺炎的患者,并探讨了其诊断和治疗策略。本案例患者在使用双重血浆置换、非诺贝特、omega-3脂肪酸等降脂药物及其他治疗后病情得到显著改善,顺利分娩一活婴,为该疾病的诊治和妊娠期高脂血症的管理提供了很好的参考意义。Acute pancreatitis during pregnancy is a rare but potentially serious disease that may even endanger the life of the mother and child. Therefore, timely diagnosis and effective treatment are very important to improve maternal and infant prognosis. Gallstone disease and hypertriglyceridemia are common causes of acute pancreatitis during pregnancy. The highest risk of complications is acute pancreatitis caused by hypertriglyceridemia. The treatment of this type of pancreatitis is difficult in the management of hyperlipidemia during pregnancy. At present, there are no guidelines at home or abroad. This article reports a case of pregnancy complicated with acute pancreatitis, and discusses its diagnosis and treatment strategy. In this case, the patient’s condition was significantly improved after the use of lipid-lowering drugs such as double plasma exchange, fenofibrate, omega-3 fatty acids and other treatments, and a live baby was delivered successfully, which provided a good reference for the diagnosis and treatment of this disease and the management of hyperlipidemia during pregnancy.
缺血性卒中是一种高致残率和致死率的脑血管疾病,早期治疗以溶栓和神经保护为主。神经保护剂可改善溶栓再通引发的缺血再灌注损伤,但因存在脑靶向性不足和作用靶点单一等缺陷,在临床应用中疗效欠佳。聚多巴胺纳米颗粒是一种具有自由基清除、多功能修饰、光热转换等特性的纳米材料,在神经保护、药物靶向、多靶点治疗方面具有独特优势,为突破目前神经保护治疗的局限提供了一个多功能集合平台。本文总结了聚多巴胺纳米颗粒的抗炎抗氧化的神经保护作用,系统阐述了聚多巴胺纳米颗粒通过各种途径促进神经保护剂靶向大脑,并结合其本身的自由基清除功能发挥多靶点治疗,为疗效确切的脑保护治疗方案的开发和应用提供新的策略。Ischemic stroke is a cerebrovascular disease with a high disabling and lethal rate, and early treatment is mainly thrombolysis and neuroprotection. Neuroprotective agents can improve ischemia-reperfusion injury caused by thrombolytic recanalization, but they have poor efficacy in clinical application due to shortcomings such as insufficient brain targeting and single target. Polydopamine nanoparticles are nanomaterials with the characteristics of free radical scavenging, multifunctional modification, photothermal conversion, etc., which have unique advantages in neuroprotection, drug targeting, and multi-target therapy, and provide a multifunctional platform for breaking through the limitations of current neuroprotective therapy. In this paper, we summarize the neuroprotective effects of polydopamine nanoparticles on anti-inflammatory and antioxidant effects, and systematically elaborate that polydopamine nanoparticles promote the targeting of neuroprotective agents to the brain through various pathways, and combine their own free radical scavenging functions to exert multi-target therapy, providing a new strategy for the development and application of brain protection therapy regimens with definite efficacy.
目的采用meta分析方法对比Viabahn覆膜支架与金属裸支架(BMS)治疗股腘动脉硬化闭塞症(ASO)的效果。方法检索筛选中国生物医学文献数据库、万方医学网、中国知网、Embase、Web of Science、Cochrane Library和PubMed数据库关于以Viabahn...
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目的采用meta分析方法对比Viabahn覆膜支架与金属裸支架(BMS)治疗股腘动脉硬化闭塞症(ASO)的效果。方法检索筛选中国生物医学文献数据库、万方医学网、中国知网、Embase、Web of Science、Cochrane Library和PubMed数据库关于以Viabahn覆膜支架(Viabahn组)及BMS(BMS组)治疗股腘ASO的随机对照研究,检索时间为建库至2022年4月30日;依据纳入及排除标准筛选文献。采用Cochrane RevMan 5.3软件分析组间技术成功率、12个月一/二期通畅率、靶病变血管重建(TLR)率和/或截肢率。结果最终纳入9篇文献,含Viabahn组424例、BMS组469例共893例患者。Viabahn组12个月一期通畅率高于BMS组[比值比(OR)=1.90,95%CI(1.23,2.92),P=0.004],而其TLR率低于BMS组[OR=0.44,95%CI(0.26,0.76),P=0.003],组间技术成功率[风险差异(RD)=0,95%CI(-0.01,0.02),P=0.59]、12个月二期通畅率[OR=1.48,95%CI(0.96,2.29),P=0.07]及截肢率[RD=0,95%CI(-0.02,0.03),P=0.79]差异均无统计学意义。结论Viabahn覆膜支架及BMS用于治疗股腘动脉ASO可提高12个月一期通畅率、降低TLR率,二者12个月二期通畅率及截肢率相当。
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