过敏性紫癜(Henoch-Schönlein purpura, HSP)又称为IgA血管炎,是由IgA免疫复合物沉积介导的全身性小血管炎。HSP以儿童最常见,成人较为少见。临床上以皮肤紫癜最多见,可伴有关节、胃肠道及肾脏等各系统症状。当腹部症状先于紫癜出现时,易被缺乏相关经验的临床医生误诊为急腹症、急性阑尾炎、消化道出血等疾病。现报道1例以腹部症状为主的成人混合型HSP,目的在于提高临床医生对HSP的诊治水平,避免延误患者的诊治。Henoch-Schönlein purpura (HSP), also known as IgA vasculitis, is a systemic small vasculitis mediated by IgA immune complex deposition. HSP is most common in children and less common in adults. The most common clinical skin purpura, can be accompanied by joint, gastrointestinal and kidney and other system symptoms. When the abdominal symptoms appear before purpura, it is easy to be misdiagnosed as acute abdomen, acute appendicitis, gastrointestinal bleeding and other diseases by clinicians who lack relevant experience. A case of adult mixed HSP with abdominal symptoms was reported in order to improve the diagnosis and treatment of HSP by clinicians and avoid delay in diagnosis and treatment.
腹壁子宫内膜异位症恶变的病例罕见,其发病机制尚未明确,利用基因检测可以为研究提供新方向,进一步完善诊断标准及治疗方案。本文报道1例腹壁子宫内膜透明细胞癌,并复习相关文献来介绍该疾病,以及了解其临床特征、诊断及鉴别诊断、治疗、预后因素,以提高该疾病的诊疗水平。The malignant transformation of abdominal endometriosis is rare, and its pathogenesis is not yet clear. The use of genetic detection can provide a new direction for research, and further improve the diagnostic criteria and treatment plan. This paper reports a case of clear cell carcinoma of abdominal wall endometrial, reviews relevant literature to introduce the disease, and understands its clinical features, diagnosis, differential diagnosis, treatment and prognostic factors, in order to improve the level of diagnosis and treatment of this disease.
类器官(organoids)是通过细胞分选和三维培养建立的创新体外模型,在妇科疾病建模、药物筛选及肿瘤个体化治疗中展现出重要价值。作为全球高发的妇科恶性肿瘤,子宫内膜癌(endometrial cancer)的发病率逐年上升且呈年轻化趋势。尽管类器官技术尚未进入临床转化阶段,但其为探索该疾病的精准治疗提供了全新平台。本文综述类器官在子宫内膜癌研究中的最新进展。Organoids are innovative in vitro models established through cell sorting and three-dimensional culture, demonstrating significant value in gynecological disease modeling, drug screening, and personalized cancer treatment. As a highly prevalent gynecological malignancy worldwide, the incidence of endometrial cancer is increasing year by year and showing a trend of younger age of onset. Although the organoid technology has not yet reached the stage of clinical translation, it provides a new platform for exploring the precise treatment of this disease. This paper reviews the latest progress of organoids in the research of endometrial cancer.
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