缺血性卒中是一种高致残率和致死率的脑血管疾病,早期治疗以溶栓和神经保护为主。神经保护剂可改善溶栓再通引发的缺血再灌注损伤,但因存在脑靶向性不足和作用靶点单一等缺陷,在临床应用中疗效欠佳。聚多巴胺纳米颗粒是一种具有自由基清除、多功能修饰、光热转换等特性的纳米材料,在神经保护、药物靶向、多靶点治疗方面具有独特优势,为突破目前神经保护治疗的局限提供了一个多功能集合平台。本文总结了聚多巴胺纳米颗粒的抗炎抗氧化的神经保护作用,系统阐述了聚多巴胺纳米颗粒通过各种途径促进神经保护剂靶向大脑,并结合其本身的自由基清除功能发挥多靶点治疗,为疗效确切的脑保护治疗方案的开发和应用提供新的策略。Ischemic stroke is a cerebrovascular disease with a high disabling and lethal rate, and early treatment is mainly thrombolysis and neuroprotection. Neuroprotective agents can improve ischemia-reperfusion injury caused by thrombolytic recanalization, but they have poor efficacy in clinical application due to shortcomings such as insufficient brain targeting and single target. Polydopamine nanoparticles are nanomaterials with the characteristics of free radical scavenging, multifunctional modification, photothermal conversion, etc., which have unique advantages in neuroprotection, drug targeting, and multi-target therapy, and provide a multifunctional platform for breaking through the limitations of current neuroprotective therapy. In this paper, we summarize the neuroprotective effects of polydopamine nanoparticles on anti-inflammatory and antioxidant effects, and systematically elaborate that polydopamine nanoparticles promote the targeting of neuroprotective agents to the brain through various pathways, and combine their own free radical scavenging functions to exert multi-target therapy, providing a new strategy for the development and application of brain protection therapy regimens with definite efficacy.
1987年,Wargotz等研究者首次识别了16例具有一致特征的乳腺肿瘤病例。这些病例中的肿瘤细胞不仅极为罕见,而且独特地兼具纤维母细胞和平滑肌细胞的属性,因此被命名为“乳腺肌纤维母细胞瘤(myofibroblastoma, MFB)”。根据相关研究,MFB的典型表现为细胞形态温和,且由呈现肌纤维母细胞分化的梭形细胞构成。文献报道显示,在肌纤维母细胞瘤中,乳腺处的发病率仅为10%左右。截至2017年数据统计,国内所报道病例仅20余例。由于该肿瘤发病率极低,目前对其认识十分有限,且该病缺乏特异临床表现、影像学上存在差异、术前诊断较困难,极易引起误诊。本文报道了一例罕见的乳腺肌纤维母细胞瘤病例,从临床诊治角度出发,总结本次病例经验,提炼关键诊断线索,旨在加深临床医生对乳腺MFB的了解,对于避免误诊误治有重要意义。In 1987, Wargotz et al. identified for the first time 16 cases of breast tumors with consistent features. The tumor cells in these cases are not only extremely rare, but also uniquely possess both fibroblastocyte and smooth muscle cell properties, hence the name “myofibroblastoma (MFB)”. According to studies, MFBs typically appear to have mild cell morphology and consist of spindle-shaped cells that exhibit myofibroblast differentiation. Literature reports show that in myofibroblastoma, the incidence in the breast is only about 10%. As of 2017, only about 20 cases have been reported in China. Due to the extremely low incidence of this tumor, the current understanding of the disease is very limited, and the lack of specific clinical manifestations, differences in imaging, and difficulty in preoperative diagnosis can easily lead to misdiagnosis. From the perspective of clinical diagnosis and treatment, this article summarizes the experience of this case and extracts the key diagnostic clues, aiming to deepen clinicians’ understanding of breast MFB, which is of great significance to avoid misdiagnosis and mistreatment.
肥胖与众多生殖系统疾病密切相关,如月经不调、生殖细胞质量下降以及流产等。肥胖通过DNA甲基化、组蛋白修饰以及非编码RNA表达等表观遗传学途径广泛影响卵母细胞和胚胎发育成熟的关键过程,这种影响不仅局限于胚胎发育阶段,还可能通过表观遗传修饰的跨代遗传对后代健康带来不良后果。本文对与母源肥胖导致卵母细胞质量下降相关的表观遗传学机制的研究进展进行综述,并联系已报道的相关机制提出干预标靶,以期改善表观遗传修饰对卵母细胞质量的消极影响。Obesity is closely associated with numerous reproductive system disorders, such as irregular menstruation, decreased germ cell quality, and miscarriages. Obesity broadly affects key processes in oocyte and embryo developmental maturation through epigenetic pathways, including DNA methylation, histone modification, and non-coding RNA expression. This impact is not limited to the embryonic development stage but may also lead to adverse outcomes for offspring health through the transgenerational inheritance of epigenetic modifications. This article reviews the research progress on the epigenetic mechanisms related to decreased oocyte quality caused by maternal obesity and proposes intervention targets based on reported related mechanisms, aiming to mitigate the negative effects of epigenetic modifications on oocyte quality.
目的系统整合减重代谢术后患者饮食管理真实体验的质性研究。方法检索中国知网、万方数据库、维普网、中国生物医学文献数据库、Web of Science、PubMed、Cochrane Library、Scopus、Embase数据库中关于减重代谢术后饮食管理体验的质性...
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目的系统整合减重代谢术后患者饮食管理真实体验的质性研究。方法检索中国知网、万方数据库、维普网、中国生物医学文献数据库、Web of Science、PubMed、Cochrane Library、Scopus、Embase数据库中关于减重代谢术后饮食管理体验的质性研究,检索时限均为建库至2024年5月31日。采用澳大利亚乔安娜布里格斯研究所循证卫生保健中心推荐的质性研究质量评价标准评价文献,采用汇集性Meta整合方法对文献结果进行整合。结果共纳入18篇文献,提炼出69个核心结果,形成9个类别,汇总成饮食管理认知现状、饮食管理对患者的影响、饮食管理策略、饮食管理随访的负性体验4个整合结果。结论医护人员应加强对减重代谢术后患者饮食管理知识的普及与教育,优化饮食管理策略,引入正向反馈机制,并构建多元社会支持体系,增强患者参与饮食管理的积极性,促进术后全面康复。
原发性乳腺血管肉瘤(primary breast angiosarcoma,PBA)及卵巢血管肉瘤均为罕见的、具有高度侵袭性和转移潜力的肿瘤,临床上同时罹患以上两种肿瘤的病例极为罕见。以上两种肿瘤在临床上均无明显特征性表现,容易发生漏诊、误诊。为帮助...
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原发性乳腺血管肉瘤(primary breast angiosarcoma,PBA)及卵巢血管肉瘤均为罕见的、具有高度侵袭性和转移潜力的肿瘤,临床上同时罹患以上两种肿瘤的病例极为罕见。以上两种肿瘤在临床上均无明显特征性表现,容易发生漏诊、误诊。为帮助临床医生早期诊断此病,现回顾性分析2023年8月收入暨南大学附属第一医院的经手术病理证实的1例PBA患者的临床资料及超声表现。该患者术后4个月经阴道超声发现左侧卵巢肿物,术后病理提示为成熟囊性畸胎瘤合并血管肉瘤。本文亦提及卵巢血管肉瘤的二维超声图像及彩色多普勒超声图像特点,并结合文献进行总结、归纳。
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