高迁移率族蛋白B1(high mobility group box 1,HMGB1)在心肌梗死后的炎性反应和细胞死亡过程中扮演着关键角色。细胞焦亡,作为一种新发现的程序性细胞死亡形式,与心肌缺血再灌注损伤紧密相关。目前,心肌梗死相关的死亡机制研究仍面临诸...
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高迁移率族蛋白B1(high mobility group box 1,HMGB1)在心肌梗死后的炎性反应和细胞死亡过程中扮演着关键角色。细胞焦亡,作为一种新发现的程序性细胞死亡形式,与心肌缺血再灌注损伤紧密相关。目前,心肌梗死相关的死亡机制研究仍面临诸多挑战,特别是在细胞死亡类型的识别及其调控途径方面尚未完全阐明。
载脂蛋白(Apolipoprotein)是与脂质结合,形成脂蛋白的蛋白质分子,它主要负责脂质的运输和代谢,根据其功能和结构特性,载脂蛋白可分为A类、B类、C类、E类以及脂蛋白(a),其主要的载脂蛋白如ApoA1、ApoB和ApoE各自承担着独特的职能,影响着人体的脂质代谢和心血管健康。既往研究表明,Apolipoprotein异常表达与多种疾病的发生和发展密切相关,本文将从载脂蛋白A1 (ApoA1)、载脂蛋白B (ApoB)及两者比值(ApoB/ApoA1)的研究进展入手进行概述。Apolipoproteins are protein molecules that bind with lipids to form lipoproteins. It is mainly responsible for the transportation and metabolism of lipids. They can be classified into various classes based on their functional and structural characteristics, including apolipoprotein A, B, C, E, and lipoprotein (a). Key proteins, such as ApoA1, ApoB, and ApoE each have unique functions that impact lipid metabolism and cardiovascular health in the human body. Research conducted in the past indicates that unusual levels of apolipoproteins are strongly linked to the onset and progression of multiple diseases. This article will summarize the research progress of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and their ratio (ApoB/ApoA1).
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