Objective Cisplatin exerts its cytotoxic effect through distinct DNA lesions,leading to peripheral *** risk of sensory neuropathy is a common problem during cancer treatment with cisplatin,leading to somatic ***,data ...
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Objective Cisplatin exerts its cytotoxic effect through distinct DNA lesions,leading to peripheral *** risk of sensory neuropathy is a common problem during cancer treatment with cisplatin,leading to somatic ***,data focussing on cisplatin-induced impairment of the autonomic nervous system are *** present study was aimed to investigate the effect of recombinant human erythropoietin（rhEPO）on cisplatin-induced visceral *** C57BL/6 mice were treated either with cisplatin（2 mg/kg,once per week）or with cisplatin（2 mg/kg,once per week）plus rhEPO （40μg/kg,3 times per week）for 8 *** were treated with *** quantify the visceromotor response（VMR）at week 9,standardized electrodes were implanted into the external oblique musculature for electromyographic *** that,animals were decapitated and dorsal root ganglia（DRG）was removed for transmission electron microscopy *** Cisplatin-treated mice showed a significant increase of VMR compared to the controls[（7080±969）vs（2864±279）;P0.001],while rhEPO dramatically counteracted this effect[（2962±336）vs（7080±969）;P0.001）].Transmission electron microscopy revealed cisplatin-induced structural lesions of nuclear membrane in DRG cells,which could be ameliorated by *** Erythropoietin can significantly ameliorate the cisplatin-induced visceral hyperplasia and DRG nuclear membrane structure damage in mice,indicating a neuroprotective role of erythropoietin.
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