目的:探讨达格列净治疗早期糖尿病肾病患者的临床效果及对其安全性的影响。方法:选择2022年1月—2023年1月于桂林医学院第二附属医院收治的70例早期糖尿病肾病患者作为观察对象,根据不同治疗方法将其进行分组,其中,35例患者采取度拉糖肽治疗,纳入对照组,35例患者在对照组基础上联合达格列净治疗,纳入观察组。比较两组临床疗效、血糖水平、肾功能指标和安全性。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组治疗后的空腹血糖(FPG)、餐后2 h血糖(2 h PG)和尿素氮(BUN)、血肌酐(Scr)均低于对照组,差异均有统计学意义(P<0.05)。结论:达格列净在早期糖尿病肾病治疗中显示出良好的临床效果,不仅能提高患者治疗总有效率,还能降低其血糖和改善肾功能,且用药不良反应少,安全性较高。
红枣作为一种药膳同源果实,在我国已有三千多年历史,其富含多糖、黄酮、多酚、三萜酸等多种生物活性成分,具有抗氧化、抑制炎症、免疫调节、改善肠道菌群及调节糖脂代谢异常等作用。本文对红枣活性成分及其作用与机制研究的最新进展,以及其对心血管代谢性疾病,如动脉粥样硬化、高血压、高血脂以及糖尿病及其并发症的影响进行综述,旨在为红枣的药用开发和临床应用提供参考。Jujube, as a medicinal and dietary cognate fruit, has a history of more than 3000 years in China. It is rich in polysaccharides, flavonoids, polyphenols, triterpene acids and other bioactive components. It has the functions of anti-oxidation, inhibiting inflammation, immune regulation, improving intestinal flora and regulating abnormal glucose and lipid metabolism. In this paper, the latest progress of the active ingredients of jujube and their effects and mechanisms, as well as their effects on cardiovascular metabolic diseases such as atherosclerosis, hypertension, hyperlipidemia, diabetes and its complications were reviewed, aiming to provide references for the medicinal development and clinical application of jujube.
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