目的探讨生物制剂治疗神经白塞综合征(NBS)的疗效。方法在PubMed、Cochrane Library、Embase、Web of Science、中国知网、万方、维普、中国生物医学文献数据库中检索关于生物制剂治疗NBS的研究,筛选收集符合纳入标准的文献,提取数据后...
详细信息
目的探讨生物制剂治疗神经白塞综合征(NBS)的疗效。方法在PubMed、Cochrane Library、Embase、Web of Science、中国知网、万方、维普、中国生物医学文献数据库中检索关于生物制剂治疗NBS的研究,筛选收集符合纳入标准的文献,提取数据后应用Stata 16.0软件进行Meta分析。结果共纳入9项研究,140例NBS患者进行分析,92%的受试患者对生物制剂治疗有反应(95%CI:0.76~1.08)。研究间无明显异质性(I^(2)=0%)。结论生物制剂是治疗NBS尤其是难治性病例的有效方法,但后续还需要更多大规模高质量对照研究以准确评估生物制剂在NBS患者中疗效和安全性。
目的:构建基于甘油三酯葡萄糖指数(triglyceride-glucose index, TyG)联合预测冠状动脉粥样硬化性心脏病[以下简称为冠心病(coronary heart disease, CHD)]患病风险的预测模型,并验证该模型的预测性能。方法:选取2020年1月至2023年3月泰安市中心医院收治的已行冠状动脉造影检查的患者为建模研究对象,根据冠状动脉造影结果分为冠心病组(732例,67.97%)和非冠心病组(365例,33.03%),比较两组一般资料及临床特征,采用多因素Logistic回归分析构建预测模型,绘制该预测模型的受试者工作特征(receiver operating characteristic, ROC)曲线及曲线下面积(area under the curve, AUC)分析评价该模型的预测效能,再通过选取2024年1月至2024年12月山东大学第二医院收治的已行冠状动脉造影检查的患者为验证模型的研究对象进行模型的外部验证。结果:TyG指数、年龄、纤维蛋白原是CHD发生的独立危险因素,既往是否服用阿司匹林是CHD发生的独立保护因素。男性更容易患CHD,该预测模型ROC为0.706,灵敏度为0.643,特异度为0.551。对该模型进行外部验证,模型验证的ROC曲线AUC为0.649 (95% CI: 0.611~0.687),该模型具有良好的预测性能。结论:本研究构建的基于TyG指数联合性别、年龄、纤维蛋白原、服用阿司匹林史对CHD的发生具有良好的预测性能。Objective: To construct a prediction model based on the triglyceride-glucose index (TyG) for predicting the risk of coronary atherosclerotic heart disease (hereinafter referred to as coronary heart disease, CHD), and to verify the prediction performance of this model. Methods: Those who underwent coronary angiography at Tai’an Central Hospital from January 2020 to March 2023 were selected as the modeling study subjects. According to the results of coronary angiography, the patients were divided into the CHD group (732 cases, 67.97%) and the non-D group (365 cases, 33.03%). The general information and clinical characteristics of the two groups were compared. A prediction model was constructed using multivariate Logistic regression analysis, and the receiver operating characteristic (ROC) curve and the area under the curve (AUC) of the prediction model were drawn to evaluate prediction performance of the model. Then, the external validation of the model was performed by selecting patients who underwent coronary angiography at the Second Hospital of Shandong University from January 2024 to December 2024 as the study subjects for the validation model. Results: TyG index, age, and fibrinogen independent risk factors for the occurrence of CHD, and the history of taking aspirin was an independent protective factor for the occurrence
背景:帕金森病(Parkinson’s Disease, PD)是继阿尔茨海默病之后第二大神经退行性疾病。随着我国社会老龄化的加剧,帕金森病患者数量激增。认知障碍等非运动症状是帕金森病患者日常生活的主要影响因素,而临床上常规治疗帕金森病的方式对认知障碍几乎无效,其生物学相关机制也尚不明确。目的:总结归纳运动了干预对帕金森病患者认知障碍的作用以及潜在的生物学机制。方法:遵循系统综述和荟萃分析指南(Preferred Reporting Items for Systematic Reviews and Meta-Analysis, PRISMA),共纳入42篇文献。结果:这些研究是根据整体认知和特定认知域(执行功能、工作记忆、语言、记忆和视觉空间功能)进行分类的。并且,运动干预帕金森患者认知的生物学机制非常复杂。在分子水平上,有氧运动可增加血清神经营养因子水平、促进AMPA型谷氨酸受体表达和多巴胺分泌。在细胞水平上,对多巴胺能神经元有保护作用。在组织水平上,可增大海马体积和增强功能连接。结论:持续数月的有氧运动训练对帕金森病患者的认知有有益,但确切的生物学机制尚不清楚。未来的研究应探索帕金森病患者的个性化运动方案。Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease following Alzheimer’s disease. As the population aging increases, the number of patients with PD is growing rapidly. Cognitive impairment and other non-motor symptoms have become a main factor in decline of quality of life in patients with PD. However, the current clinical treatments for PD have poor effectiveness on cognitive impairment, and the underlying biological mechanism is still unclear. Objectives: This study conducts a systematic review of the effects of exercise intervention on cognitive impairment in PD, and potential biological mechanism. Methods: Adhering to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, a total of forty-two studies were included. Results: These studies were classified based on whether they evaluated global cognition or specific cognitive domains such as executive functions, working memory, language, memory, and visuospatial function. Moreover, molecular, cellular, and systemic changes occur under the effect of exercise. At the molecular level, aerobic exercise is found to increase the serum level of neurotrophic factors, the expression of AMPA-type glutamate receptor, and the secretion of dopamine. At the cellular level, it offers a protective effect on dopaminergic neurons. At the systemic level, it is associated with enhanced hippocampus volume and functional connectivity. Conclusion: Several-month aer
暂无评论