[Snmmary]Alzheimer's disease(AD)is the most common neurodegenerative disesae in eldely people,clin-ical manifestations of hypomnesis,progressive smart recession,accompanied by personality *** tan-gles and extracel...
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[Snmmary]Alzheimer's disease(AD)is the most common neurodegenerative disesae in eldely people,clin-ical manifestations of hypomnesis,progressive smart recession,accompanied by personality *** tan-gles and extracellular senile plaques together with neuronal loss and cortical atrophy are characteristic neuropathologi-cal features of the *** Aβ has received particular attention among the pathogenesis of neuronal injury in AD,Recent research is evidence to assume that Na-K-ATPase also plays an important role in the AD ***-K-ATPase of the brain tissue locates in the cell *** is a material basis of maintaining neuronal excitatory transmission and intracellular environment by transporting ions against the concentration gradient after hydrolyzing ***-K-ATPase is adimermainly consisting of α-subunits,β-subunits and γ-*** review aims to discuss the relationship between AD and Na-K-ATPase,It is indicated Na-K-ATPase subunitin maybe a new theoretical basis for research aims of the prevention and treatment of AD.
Na+-K+-ATP酶是通过水解ATP逆化学梯度转运离子,最终将3个Na+泵出细胞外的同时泵入2个K+到细胞内,释放ADP能量作为动力,把ATP末端磷酸基团添加到Na+-K+-ATP酶的活性部位上,从而实现自身的磷酸化,改变蛋白构型.Na+-K+-ATP酶不仅参与离子转运,维持细胞质膜对离子的通透性、细胞膜电位稳态、神经细胞兴奋传导、能量代谢,维持细胞内环境稳定等作用,而且还在神经系统发育及细胞形态的维持上起到重要作用.简之,Na+-K+-ATP酶是维持钠钾跨膜梯度稳定的关键调节器.阿尔茨海默病(Alzheimer' s dis-ease , AD)是老年人常见的，以记忆力减退、认知功能障碍、人格改变为主要特征的中枢神经系统退行性疾病，是以神经细胞内出现老年斑(主要由β淀粉样蛋白组成)、神经原纤维缠结、大脑皮质和海马等部位神经细胞减少为主要病理特点。在AD的早起阶段p淀粉样蛋白(A田的积累伴随Na+-K+-ATP酶活性的降低，但是这种现象背后的分子机制尚未研究清楚。最新研究认为Aβ寡具体形成可能有α1β1亚基的参与，它的形成抑制Na+-K+-ATP酶活性。笔者认为β淀粉样蛋白是Na+-K+-ATP酶的一个新的生理调节器。
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