Objective To study the dynamic characteristics of norepinephrine(NE)release in hypothalamus followed by electrical stimulation in locus coeruleus in the rat model of stress-inducedhypertension(SIH)and explore the role...
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Objective To study the dynamic characteristics of norepinephrine(NE)release in hypothalamus followed by electrical stimulation in locus coeruleus in the rat model of stress-inducedhypertension(SIH)and explore the role of angiotensin type 2 receptor in the pathogenesis of *** 44 rats were randomly divided into control(n=20)and stress groups(n=24).The hypertension model was established by combining noise and foot-shock *** the end of modeling,NE release in the hypothalamus by electrical stimulation in locus coeruleus was studied and NE signal was recorded by carbon fiber *** peak value,the time to peak and half-life period of NE signal in both group rats were *** The peak value of NE signal in the hypothalamic followed by electrical stimulation in locus coeruleus in SIH rats were more than in controls(P<0.01).Intraperitoneal injection of PD123,319(AT2 receptor antagonist)potentiated electrical stimulation in locus coeruleus induced NE release in the hypothalamus in SIH rats and elevated blood pressure(P<0.05),whereas intracerebroventricular injection of CGP42112(AT2 receptor agonist)inhibited the NE release and reduced the heart rate(P<0.05).Conclusions Combining noise and foot-shock stresses increased the secretion of NE in the hypothalamus followed by electrical stimulation in locus coeruleus in *** type 2 receptor plays an inhibition effect on NE release in hypothalamus in SIH *** findings suggest that angiotensin type 2 receptor can be a pharmacology target for treatment of SIH.
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