Epilepsy is a common neurological disorder characterized by periodic and unpredictable *** junctions have recently been proposed to be involved in the generation,synchronization and maintenance of seizure *** present ...
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Epilepsy is a common neurological disorder characterized by periodic and unpredictable *** junctions have recently been proposed to be involved in the generation,synchronization and maintenance of seizure *** present review mainly summarizes recent reports concerning the contribution of gap junctions to the pathophysiology of epilepsy,together with the regulation of connexin after clinical and experimental seizure *** anticonvulsant effects of gap junction blockers both in vitro and in vivo suggest that the gap junction is a candidate target for the development of antiepileptic *** is also of interest that the roles of neuronal and astrocytic gap junctions in epilepsy have been investigated independently,based on evidence from pharmacological manipulations and connexin-knockout *** studies using more specific manipulations of gap junctions in different cell types and in human epileptic tissue are needed to fully uncover the role of gap junctions in epilepsy.
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