Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue(WAT)regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to *** found...
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Our objective was to investigate the mechanisms by which the endogenous CRHR2 in white adipose tissue(WAT)regulates metabolic activities associated with lipogenesis and lipolysis under continuous exposure to *** found that hypobaric hypoxia at a simulated altitude of 5,000m significantly reduced the body weight,food intake,and WAT mass of *** also accelerated lipolysis and suppressed lipogenesis in *** with astressin 2B,a selective CRHR2 antagonist,partly but significantly attenuated the hypoxia-induced reductions in body weight and WAT mass by blocking the c AMP–protein kinase A(PKA)–hormone-sensitive lipase(HSL)/perilipin signalling *** 2B treatment failed to attenuate hypoxia induced lipogenic *** conclusion,activation of endogenousWAT Ucn2/3 autocrine/paracrine pathway was involved in hypoxia induced lipolysis via CRHR2-c AMP–PKA signalling *** study provides the novel understanding of local CRHR2 signaling pathway playing important role in WAT loss and lipid metabolism under hypoxia.
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