Objective:MicroRNA-155（miR-155） regulates T cell differentiation and *** has also been associated with HIV ***,it remains unclear whether miR-155 is related to the T cell response in HIV-infected individuals（e.g.,T...
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Objective:MicroRNA-155（miR-155） regulates T cell differentiation and *** has also been associated with HIV ***,it remains unclear whether miR-155 is related to the T cell response in HIV-infected individuals（e.g.,T cell activation and exhaustion）.Methods:We performed a cross-sectional study involving 121 HIV-1 infected patients with HAART and 43 HAART naive *** miR-155 levels in the peripheral blood were detected by quantitative reverse transcription-PCR.T cell immune activation,exhaustion,and homeostasis were detected by the expression of CD38,PD-1 and CD 127 via flow ***:The levels of miR-155 in the total peripheral blood mononuclear cells,CD4+,and CD8+ T cells from HIV-1 patients were increased（P < 0.01）.Discord controllers and HAART naive patients also exhibited a higher percentage of CD8+CD38 T cells and a lower percentage of CD4+CD127+ and CD8+CD127+ T cells（P < 0.05）.We also found higher levels of PD-1 expression on the CD4+ and CD8+ T cells of HTV-1 patients（P < 0.05）.Conclusion:Our findings suggest that miR-155 levels in the peripheral blood of HIV-1 patients are increased and associated with T cell ***,miR-155 is a potential biomarker of the immune response following HIV-1 infection.
Objective:CD8+ T cell differentiation and response play a vital role in host defense against human immunodeficiency virus(HIV)-***-155 is an important regulator of T cell ***,the profile of miR-155 in HIV-1 infected i...
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Objective:CD8+ T cell differentiation and response play a vital role in host defense against human immunodeficiency virus(HIV)-***-155 is an important regulator of T cell ***,the profile of miR-155 in HIV-1 infected individuals and the association with CD8+ T cell differentiation are still ***:We performed a cross-sectional study involving 63 HIV-1 infected patients with highly active antiretroviral therapy(HAART),31 HAART naive patients and 35 healthy ***-155 level in CD8+ T cells was detected by quantitative reverse *** of CD8+ T cell differentiation were detected by flow ***:Discord controllers and HAART na(i|¨)ve patients showed higher percentage of effector and effector memory cells,and lower percentage of naive cells(P<0.05).Levels of miR-155 in CD8+ T cells from HIV-1 patients were increased,especially in discord controllers and HAART naive patients(P<0.01).MiR-155 were positively correlated with percentages of effector and effector memory CD8+ T cells,and negatively correlated with percentages of naive and central memory CD8+ T cells(P<0.01).Conclusion:Our findings suggest that miR-155 levels in CD8+ T cells of HIV-1 patients are increased and associated with CD8+ T cell differentiation.
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