MicroRNAs(miRNAs) are important post-transcriptional regulators that repress gene expression by binding to the 3'UTRs of their target *** are two main outcomes for the transcripts targeted by miRNAs:mRNA degradati...
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MicroRNAs(miRNAs) are important post-transcriptional regulators that repress gene expression by binding to the 3'UTRs of their target *** are two main outcomes for the transcripts targeted by miRNAs:mRNA degradation and translational *** is still unclear what factors determine whether a target transcript is degraded or translationally *** this study,we collected two classes of genes that are targeted by miR-1,miR-155,miR-16, miR-30a,and let-7b and built new
The community structures in genome-wide gene networks are indicated to the gene *** study the gene communities in a specific cell type,a cell type specific gene network should be *** clustering algorithm should be dev...
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The community structures in genome-wide gene networks are indicated to the gene *** study the gene communities in a specific cell type,a cell type specific gene network should be *** clustering algorithm should be developed to search the function-related gene *** this study,we proposed a new algorithm to implement the clustering in the large gene
Introduction The identification of genetic risk factors underlying human inherited diseases represents one of the major research directions in human genetics studies,and has harvested plenty of concerns and exploratio...
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Introduction The identification of genetic risk factors underlying human inherited diseases represents one of the major research directions in human genetics studies,and has harvested plenty of concerns and explorations on the problem of identifying genes and their products that are responsible for specific *** are structural units of proteins that often form functions,and thus
Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative *** is regarded as an important mechanism against cancer and is closely related to tissue repair,organi...
Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative *** is regarded as an important mechanism against cancer and is closely related to tissue repair,organismal aging and age-related degenerative *** cells are characterized with dramatic changes in cell morphology,gene expression pattern and epigenetic *** this study,we used an interdisciplinary strategy by taking the advantage of computational predictions and systematically designed high throughput experiments to study the gene regulatory network of senescent *** applied a combination of Hi-C,ATAC-seq and transcriptome profiling to characterize gene regulation changes at different scale in proliferating,quiescent,senescent,and reverse senescent human fibroblast ceils.A high-throughput CRISPR-Cas9 library screening combined with deep-sequencing analysis was performed to identify key senescence regulatory *** study revealed global changes of chromatin organization in senescent cells,and identified several new regulators participating this process.
Introduction Reconstruction of biological pathways is often done through mapping well-characterized pathways of model organisms to a target genome,typically through orthologous gene mapping.A limitation of such pathwa...
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Introduction Reconstruction of biological pathways is often done through mapping well-characterized pathways of model organisms to a target genome,typically through orthologous gene mapping.A limitation of such pathway-mapping approaches is that the mapped pathway models are limited by the compositions of the template pathways,i.e.,some genes in a target pathway may not have corresponding genes in the template pathways,the so-called"missing gene"problem.
Background: An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable ***, engineering of complex circuits in mammal...
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Background: An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable ***, engineering of complex circuits in mammalian cells is currently limited by the availability of well-characterized and orthogonal transcriptional repressors.
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