Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative *** is regarded as an important mechanism against cancer and is closely related to tissue repair,organi...
Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative *** is regarded as an important mechanism against cancer and is closely related to tissue repair,organismal aging and age-related degenerative *** cells are characterized with dramatic changes in cell morphology,gene expression pattern and epigenetic *** this study,we used an interdisciplinary strategy by taking the advantage of computational predictions and systematically designed high throughput experiments to study the gene regulatory network of senescent *** applied a combination of Hi-C,ATAC-seq and transcriptome profiling to characterize gene regulation changes at different scale in proliferating,quiescent,senescent,and reverse senescent human fibroblast ceils.A high-throughput CRISPR-Cas9 library screening combined with deep-sequencing analysis was performed to identify key senescence regulatory *** study revealed global changes of chromatin organization in senescent cells,and identified several new regulators participating this process.
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