Introduction Reconstruction of biological pathways is often done through mapping well-characterized pathways of model organisms to a target genome,typically through orthologous gene mapping.A limitation of such pathwa...
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Introduction Reconstruction of biological pathways is often done through mapping well-characterized pathways of model organisms to a target genome,typically through orthologous gene mapping.A limitation of such pathway-mapping approaches is that the mapped pathway models are limited by the compositions of the template pathways,i.e.,some genes in a target pathway may not have corresponding genes in the template pathways,the so-called"missing gene"problem.
Background: An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable ***, engineering of complex circuits in mammal...
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Background: An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable ***, engineering of complex circuits in mammalian cells is currently limited by the availability of well-characterized and orthogonal transcriptional repressors.
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