Nystatin is a polyene antifurgal drug to which many molds and yeasts are sersitive, including cryptococcus neoformans, candida, aspergillus, etc. To realize the mechanism of nystatin more particularly, the techniques ...
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Nystatin is a polyene antifurgal drug to which many molds and yeasts are sersitive, including cryptococcus neoformans, candida, aspergillus, etc. To realize the mechanism of nystatin more particularly, the techniques of SPR and impedance were used to investigate the interaction between nystatin and two kinds of solid-supported phospholipid membranes. The results show that nystatin could interact with pure phospholipid membranes, whether they are monolayer or bilayer. In addition, impedance spectra show that ion channels may be formed when nystatin interacted with phospholipid membranes.
The uptake of silica nanoparticles(SiNPs) with positive surface charge and negative surface charge by HepG cells,MCF-7 cells and L-02 cells were investigated by using the RITC doped in SiNPs as a synchronous fluoresce...
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The uptake of silica nanoparticles(SiNPs) with positive surface charge and negative surface charge by HepG cells,MCF-7 cells and L-02 cells were investigated by using the RITC doped in SiNPs as a synchronous fluorescent signal *** experimental results show that the uptake of SiNPs by the three kinds of cells were all a concentration-,charge-,time-,and serum-dependent endocytic *** the same kind of SiNPs,the(uptake) by the three kinds of cells all enhanced with increasing of the SiNPs concentration and incubation time and gradually reached ***,the effect of serum was different to the uptake of SiNPs with different surface *** results display that serum existed in culture medium decreased the cellular uptake of *** the serum existed in culture medium would not affect the cellular uptake of *** results provide a theoretical foundation for the further modification of SiNPs,which could improve the stability of SiNPs in the medium and made it be well applied to biomedicine.
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