白藜芦醇(Resveratrol)是一种天然存在于葡萄、浆果和花生中的多酚化合物,因其显著的抗氧化、抗炎和抗癌特性,近年来在乳腺癌研究中备受关注。文章综述了白藜芦醇在乳腺癌细胞中的分子机制及其在抗肿瘤过程中的作用。白藜芦醇通过靶向多种信号分子,抑制乳腺癌细胞的增殖,诱导细胞凋亡和自噬,抑制细胞迁移和侵袭,并重组细胞代谢。此外,白藜芦醇与化疗和放疗药物具有协同作用的潜力。尽管临床前研究结果令人鼓舞,但白藜芦醇的生物利用度和稳定性问题仍需解决。未来的研究应聚焦于优化白藜芦醇的递送系统,深入揭示其分子作用机制,并评估其长期使用的安全性和有效性,为乳腺癌患者提供更有效的治疗选择。Resveratrol, a polyphenolic compound naturally found in grapes, berries, and peanuts, has attracted significant attention in recent years due to its potent antioxidant, anti-inflammatory, and anti-cancer properties. This review summarizes the molecular mechanisms of resveratrol in breast cancer cells and its role in tumor suppression. Resveratrol exerts its effects by targeting multiple signaling molecules, thereby inhibiting the proliferation of breast cancer cells, inducing apoptosis and autophagy, suppressing cell migration and invasion, and reprogramming cellular metabolism. Additionally, resveratrol shows potential synergistic effects when combined with chemotherapeutic and radiotherapeutic agents. Despite promising preclinical results, issues related to the bioavailability and stability of resveratrol remain to be addressed. Future research should focus on optimizing resveratrol delivery systems, deeply elucidating its molecular mechanisms, and evaluating the safety and efficacy of long-term use, with the ultimate goal of providing more effective treatment options for breast cancer patients.
目的探究氯沙坦钾联合复方石韦颗粒治疗慢性肾小球肾炎的临床疗效及对患者血清炎症因子[白细胞诱素-1(LKN-1)、白细胞介素-33(IL-33)及肿瘤坏死因子-α(TNF-α)]水平的影响。方法选取2019年1月至2020年12月衡阳市中心医院收治的95例慢性肾小球肾炎患者作为研究对象,按照随机数字表法分为观察组(n=47)与对照组(n=48)。对照组单用氯沙坦钾治疗,观察组采用氯沙坦钾联合复方石韦颗粒治疗,比较两组临床疗效、治疗前后尿常规指标[尿红细胞计数(RBC)、24 h尿蛋白定量(24 h Upro)、尿β_(2)-微球蛋白(β_(2)-MG)]和血清炎症因子水平及急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)、健康状况调查简表(SF-36)评分。结果观察组治疗总有效率为95.74%,明显高于对照组的72.92%,差异有统计学意义(P<0.05)。治疗后,两组RBC、24 h Upro、β_(2)-MG水平均明显低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清LKN-1、IL-33及TNF-α水平均明显低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组APACHEⅡ评分均明显低于治疗前,SF-36评分均明显高于治疗前,且观察组APACHEⅡ评分低于对照组,SF-36评分高于对照组,差异有统计学意义(P<0.05)。两组治疗过程中均未发生明显不良反应。结论氯沙坦钾联合复方石韦颗粒治疗慢性肾小球肾炎效果显著,能改善患者肾功能,降低血清LKN-1、IL-33及TNF-α水平,提高患者健康状况及生命质量。
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