Astaxanthin (ATX), the most abundant flavonoids in propolis, has been proven to exert neuroprotective property against cerebral ischemiainduced ***, the mechanisms by which ATX mediates its therapeutic effects in vitr...
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Astaxanthin (ATX), the most abundant flavonoids in propolis, has been proven to exert neuroprotective property against cerebral ischemiainduced ***, the mechanisms by which ATX mediates its therapeutic effects in vitro are *** the present study, the article explored the underlying mechanisms involved in the protective effects of ATX via the PI3K/Akt/GSK3β/Nrf2 signaling pathway in SHSY5Y *** study of mechanism, the phosphoinositide 3 kinase (PI3K)Akt inhibitor LY294002, Glycogen synthase kinase 3β(GSK3β) inhibitor LiCl were *** ATX for 24h significantly reduced the OGD induced viability loss, apoptotic rate and attenuated OGDmediated ROS *** addition, ATX inhibited OGDinduced mitochondrial membrane potential, decreased Bcl2/Bax ***3K/Akt/GSK33/Nrf2 signaling pathway activation in SHSY5Y was tested by Western ***2 expression was increasing by ATX and counteracted by PI3K/Akt inhibitor LY294002, GSK3β inhibitor LiCl in ***2 Immunocytochemistry showed Nrf2 nuclear translocation was increasing by ATX and counteracted by LY294002 or LiCl in SHSY5Y, *** may be suggested that astaxanthin against cerebral ischemiainduced apoptosis in vitro via a programmed PI3K/Akt/GSK3β/Nrf2 signaling pathway in vitro.
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