The incidence of colorectal cancer（CRC） is alarming among younger *** no effective chemopreventive drug available in the market,researchers have been searching for alternative strategies against CRC that are in ***,...
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The incidence of colorectal cancer（CRC） is alarming among younger *** no effective chemopreventive drug available in the market,researchers have been searching for alternative strategies against CRC that are in ***,we tested the cancer-preventive properties of Ganoderma lucidum（Lingzhi） polysaccharides（GLP）,along with the saponins extracted from Gynostemma pentaphyllum（GpS）,an herbal tea with prebiotic-like ***,we report that saponins from Gynostemma pentaphyllum（GpS） and polysaccharides from Ganoderma lucidum（GLP together with GpS） profoundly improved the inflamed gut barrier of Apc mice by reducing polyps,shifting colonic M1 to M2 macrophages,positively reverting E-cadherin/N-cadherin ratio,and downregulating oncogenic signaling *** treatments also markedly promoted short-chain fatty acids（SCFAs）-producing bacteria and abridged sulfate-reducing bacteria in a time-dependent manner.G-protein coupled-receptors were significantly stimulated in the treated mice,accompanied by the modulated expressions of histone deacetylases,anti-cancer gut hormone PYY,and PPAPγ.These findings suggest that some of the herbal medicinal foods could modulate the relationship between the host and the GM to exert their beneficial properties to the *** study also implicates that these dietary mushroom polysaccharides and the Gp saponins have the potential to be developed as new preventive medicines against CRC.
前言：碘是人體的必需微量元素之一。世界上許多國家都曾面臨碘缺乏病(IDD)所帶來的公共衛生問題，為解決這一問題，世界衛生組織在1993 年提出了食鹽加碘政策。目的：通過查閱文獻，了解沿海地區居民膳食碘攝入狀況以及碘的主要來源。方法：本研究採用文獻探討與分析的方法，主要參考Iodine Global Network(IGN)與World Health Organization(WHO)等公開的有關世界各國膳食碘相關的資料。
目的:从霸王花中提取分离和纯化多糖,并对其理化性质、光谱学特征和结构特征进行研究。方法:霸王花经水提醇沉、脱蛋白、冷冻干燥得到水溶性粗多糖(hylocereus undatus polysaccharide,HUP),再通过DEAE-Cellulose 52纤维素柱和Sephadex G-100凝胶柱层析分离纯化,得到1种水溶性均一多糖HUP0。对获得的纯化组分采用傅里叶变换红外光谱(Fourier transform infrared spectroscopy,FT-IR)、高效分子排阻色谱、气相色谱-质谱联用和核磁共振波谱(nuclear magnetic resonance,NMR)等方法进行化学结构分析。结果:经纯化后得到均一的霸王花多糖样品HUP0,分子质量为33.24 k D,特性黏度(η)为47.16 m L/g,比旋度为+69°,平均粒径为196.96 nm;FT-IR图谱结果表明HUP0是中性糖且以β-构型为主;结合高效液相色谱、单糖组成、甲基化分析、NMR对HUP0的结构进行鉴定分析后,表明HUP0为(1→4)-β-D-半乳聚糖。
女性盆腔脏器脱垂（female pelvic organ prolapse,FPOP）是一种常见的盆底功能障碍性疾病,是指由于盆底肌肉和盆底支持组织的薄弱,导致盆腔脏器下降,从而引起的脏器位置和功能异常。FPOP多发于40岁以上的中老年女性^（[1]）,尽管不会...
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女性盆腔脏器脱垂（female pelvic organ prolapse,FPOP）是一种常见的盆底功能障碍性疾病,是指由于盆底肌肉和盆底支持组织的薄弱,导致盆腔脏器下降,从而引起的脏器位置和功能异常。FPOP多发于40岁以上的中老年女性^（[1]）,尽管不会威胁生命,但严重影响患者的生活^（[2]）。
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