Inferring gene regulatory networks based on gene expression profiles is an import topic in computational systems *** dozens methods has been proposed in the last decade, current algorithms are still suffering from low...
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Inferring gene regulatory networks based on gene expression profiles is an import topic in computational systems *** dozens methods has been proposed in the last decade, current algorithms are still suffering from low sensitivity and specificity due to the small data sample size relative to the complex gene regulatory network.
Background: MicroRNAs (miRNAs) are a class of~22nt long short non-coding ***-mediated post-transcriptional regulation could be triggered even by only 6-nt complementarity of the miRNA 5'-end "seed region"...
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Background: MicroRNAs (miRNAs) are a class of~22nt long short non-coding ***-mediated post-transcriptional regulation could be triggered even by only 6-nt complementarity of the miRNA 5'-end "seed region" to the target RNA, which confers each miRNA species the capacity to interact with multiple RNA species.
Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative *** is regarded as an important mechanism against cancer and is closely related to tissue repair,organi...
Cellular senescence refers to an irreversible cell-cycle arrest program that cell permanently loses proliferative *** is regarded as an important mechanism against cancer and is closely related to tissue repair,organismal aging and age-related degenerative *** cells are characterized with dramatic changes in cell morphology,gene expression pattern and epigenetic *** this study,we used an interdisciplinary strategy by taking the advantage of computational predictions and systematically designed high throughput experiments to study the gene regulatory network of senescent *** applied a combination of Hi-C,ATAC-seq and transcriptome profiling to characterize gene regulation changes at different scale in proliferating,quiescent,senescent,and reverse senescent human fibroblast ceils.A high-throughput CRISPR-Cas9 library screening combined with deep-sequencing analysis was performed to identify key senescence regulatory *** study revealed global changes of chromatin organization in senescent cells,and identified several new regulators participating this process.
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