Two new sterols,（22E）-cholest-4,22-diene-3β,6β-diol（1）and（23S,24R）-dimethylcholest-7-ene-3β,5α,6β-triol（3）,a sterol reported for the first time from natural sources,（22E,24S）-24-methylcholest-4,22-dien...
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Two new sterols,（22E）-cholest-4,22-diene-3β,6β-diol（1）and（23S,24R）-dimethylcholest-7-ene-3β,5α,6β-triol（3）,a sterol reported for the first time from natural sources,（22E,24S）-24-methylcholest-4,22-diene-3β,6β-diol（2）,together with a known steroid glycoside（4）and six known sterols（5-10）,were isolated from the marine bryozoan Bugula neritina inhabiting South China *** structures of the new compounds were determined on the basis of extensive spectral analysis,including 1D and 2D NMR,EI-MS,HR-EI/ESI-MS ***1-10 were evaluated for their cytotoxicity against human tumor cell lines HepG2,NCI-H460 and *** 1,2 and 5 exhibited selective inhibitions against HepG2 cancer cell line with the ICvalues of 36.6μM,52.1μM and 47.8μM,respectively,while showed inactivity to NCI-H460 and SGC7901 cell *** characteristic 3β3,6β-dihydroxyΔ nucleus in sterols 1,2and 5 was found from marine bryozoans for the first time.
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