Objective To evaluate the effects of recombinant human neuregulin-1βon a rat model of adriamycin-induced dilated *** Weight-matched adult male Sprague-Dawley rats were administered with 2.5 mg/kg adriamycin intraveno...
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Objective To evaluate the effects of recombinant human neuregulin-1βon a rat model of adriamycin-induced dilated *** Weight-matched adult male Sprague-Dawley rats were administered with 2.5 mg/kg adriamycin intravenously once a week for 10 weeks to establish models of *** measurements were obtained at 12 weeks after treatment to detect and evaluate the heart function(LVESD、LVEDD、LVEF、LVFS).The ADR-DCM rats were randomly divided into 3 groups as follows:(1) the rhNRG-1 group(rhNRG-1,n=8),in which 20wg/kg of rhNRG-1 was injected everyday via a tail vein for 10 *** negative control group(Excipient,n=8),in which excipient was injected in the same way as ***
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