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检索条件"机构=第三军医大学西南医院神经外科全军神经系统疾病微创诊治中心"

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重视脑积水的临床诊治与转化研究

重视脑积水的临床诊治与转化研究

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第八届全国创伤学术会议

作者：冯华孟辉陈志钱忠明全军神经创伤防治重点实验室第三军医大学西南医院神经外科(国家重点学科) 全军神经系统疾病微创诊治专科中心

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重视脑积水的临床诊治与转化研究

重视脑积水的临床诊治与转化研究

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首届全国脑外伤治疗与康复学术大会

作者：冯华孟辉陈志钱忠明第三军医大学西南医院神经外科(国家重点学科) 全军神经系统疾病微创诊治专科中心全军神经创伤防治重点实验室

脑积水神经外科常见疾病,从新生儿到老年人均可见发病脑积水主要表现为脑室系统扩大,但并非所有脑室系统扩大均为脑积水;脑室扩大可能为静止性而非进展性,也可能为脑组织萎缩而导致的代偿性脑室增大脑积水临床表现及影像学表现复杂、多... 详细信息

脑积水神经外科常见疾病,从新生儿到老年人均可见发病脑积水主要表现为脑室系统扩大,但并非所有脑室系统扩大均为脑积水;脑室扩大可能为静止性而非进展性,也可能为脑组织萎缩而导致的代偿性脑室增大脑积水临床表现及影像学表现复杂、多样,认识仍存在分歧较大,临床工作中常常容易出现漏诊及误诊,从而采取了不必要或错误的治疗方式

关键词：临床诊治实验组

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Implantation of neurosphere derived from murine malignant glioma cell line GL261 into C57/BL6 mice:a reliable syngeneic graft model for research on glioma-initiating cells in vivo

Implantation of neurosphere derived from murine malignant gl...

引用

中国医师协会神经外科医师分会第六届全国代表大会

作者：周椿第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

Glioma - initiating cells(GICs) have been proven to play key roles in initiation and progress of malignant ***,a mass of pervious in vivo studies were based on the heterograft model which is implanting GICs derived from primary human glioma specimens into immunodeficient *** this in vivo model could duplicate the microenvironment of malignancy and evaluate the biological features of GICs accurately is ***,we compared the biological features of neurosphere - like tumor cells derived from murine glioma cell line GL261(GL261 - NS) and neurosphere - like tumor cells of primary human glioma specimens(P - NS) in vitro and in *** found that GICs enriched in GL261 - NS,GL261 -NS and P - NS both exhibited similar increased GICs potential and drug resistance in ***,GL261 - NS in syngeneic graft model showed different enhanced tumorigenicity and better duplicated the primary human glioma histologically relative to P - NS in nude mice which were lack of immunocytes and ***,the biological features of P - NS were different among individual largely, although the patients were all diagnosed as *** studies conclude that implantation of GL261 - NS into C57/BL6 mice is a more reliable and stable syngeneic graft model for in vivo study on GICs relative to implantation of P - NS into heterogenous immunodeficient mice.

关键词： Implantation of neurosphere derived from murine malignant glioma cell line GL261 into C57/BL6 mice:a reliable syngeneic graft model for research on glioma-initiating cells in vivo

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20-hydroxyecdysoneprotects against oxidative stress- induced neuronal injuryand brain ischemic insult:involvement of NF-κ B/iNOSand ASK1-MKK4/7-JNK pathways and inhibition of ROS/RNS generation

20-hydroxyecdysoneprotects against oxidative stress- induced...

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中国医师协会神经外科医师分会第六届全国代表大会

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20-hydroxyecdysoneprotects against oxidative stress- induced neuronal injuryand brain ischemic insult:involvement of NF-κ B/iNOSand ASK1-MKK4/7-JNK pathways and inhibition of ROS/RNS generation

20-hydroxyecdysoneprotects against oxidative stress- induced...

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中国医师协会神经外科医师分会第六届全国代表大会

作者： J.Hu,C.X.Luo,W.H.Chu,W.H.Tang,L Yi,H.Feng 第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

Oxidative stress plays an important role in the pathological processes of ischemic *** antioxidants have been shown to protect against cerebralischemia injury by inhibiting oxidative stressboth in vitro and in vivo.20 - Hydroxyecdysone(20E),an ecdysteroid hormone exhibits antioxidative ***, we used an in vitro oxidative damagemodel and an in vivo ischemic model of middle cerebral artery occlusion (MCAO) to investigate the neuroprotective effects of 20Eon cerebralischemiainjury and the related *** of cells with HO led to neuronal injury,intracellular ROS/RNS generation, mitochondrial membrane potential dissipation,cellular antioxidant potential descent,the increase in malondialdehyde(MDA),the end product of lipid peroxidation and the elevation of intracellular[Ca]),which were markedly attenuated by *** of the activation of ASK1 - MKK4/7 - JNK stress signalingpathway and caspase - 3 induced by oxidative stresswere involved in the neuroprotection afforded by ***,20E reduced the expression of iNOSproteinby inhibition of NF -κB ***, the protective effect of 20E was confirmed in vivo study.20E significantly decreased infarct volume,the neurological deficit score,restore antioxidant potential and inhibited the increase in MDA and TUNEL positive and caspase - 3 positive cells in the cerebral cortex in ***,these resultssupport that 20E protects against cerebral ischemia injury through multifunctional cytoprotective pathways.

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Functional MRI and magnetoencephalography for presurgical planning in or around motor cortex of the brain:Comparision with electrical cortical stimulation

Functional MRI and magnetoencephalography for presurgical pl...

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中国医师协会神经外科医师分会第六届全国代表大会

作者：吴楠第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

Objective To prospectively evaluate functional magnetic resonance(MR) imaging and magnetoencephalography(MEG ),as compared with direct electrical cortical stimulation(DECS ),for identification of the primary motor *** 8 patinents with tumors of different aetiology in or around motor cortex were *** was performed using a T2 weighted gradient echo BOLD sequence at 1.5T MR scanner,MEG study was performed using a whole - head Omega 151 - channel gradiometer *** the functional studies,the patients were asked to perform a unilateral finger tapping motor *** and MEG localizations were compared with the results of intraoperative electrical cortical *** The MEG localization results agreed with the intraoperative electrical cortical stimulation results in 8 *** fMRI localization results agreed with the intraoperative electrical cortical stimulation results in 3 *** all 5 patients with a false localization,3 patients showed neighbouring results of fMRI and MEG,2 patients showed discordance between fMRI and *** Although fMRI could show the activations of primary motor cortex,supplementary motor cortex,premotor area and other motor - related areas,MEG seemed to be superior for locating the primary motor cortex.

关键词： MRI Functional MRI and magnetoencephalography for presurgical planning in or around motor cortex of the brain:Comparision with electrical cortical stimulation

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Effects of 900MHz electromagnetic fields exposure on learning and memory ability and histopathology of hippocampal and SVZ in adult rats

Effects of 900MHz electromagnetic fields exposure on learnin...

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中国医师协会神经外科医师分会第六届全国代表大会

作者：罗海水第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

The effects of electromagnetic fields(EMFs) emitted by mobile phones on humans central nervous system(CNS) have been the subject of a large number of experimental studies in recent years. However,those results showed were *** present study investigated the effects of 900MHz EMF on behavioral and histopathology changes of brain of adult Spraque - Dawley(SD) *** group was housed in our animal room during the exposure *** group was placed in the exposure box but not exposed to EMF(power density:0mw/cm,2 h/day for consecutive 28 days).EMF group rats were exposed to 900 MHz EMF(power density:1 mw/cm,2 h/day for consecutive 28 days) in an exposure *** of those rats were subjected to behavioral tests by Morris water maze or histologically change in SVZ(subventricular zone ) and SGZ(subgranular zone) of *** the BrdU cells in SVZand SGZ were *** showed that the latency of place navigation was significantly increased(P<0.05) at timepoints of Oh,24h, 48h and 72h after exposure,the times through platform and the time in target area were obviously decreased (P<0.05 ) in spatial probe test in EMF group rats compared with those in sham group *** structural changes of hippocampus after exposure including celluer edema,vessel stenosis and neurons loss. Apoptotic cells in hippocampus was significant increased in the exposure group(P<0.05 ).The number of BrdU cells were significantly decreased in timepoints of 7d after exposure both in SVZ and SGZ regions(P<0.05) of the EMF group;Timeoint of 3d also decreased in SVZ region(P<0.05) in comparison to sham *** results indicated that chronic exposure to 900 MHz EMF(power density:1 mw/cm ) may induce morphological structural changes of cells in the rat SVZ and hippocapus and resulted in learning and memory deficits.

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A PTEN inhibitor,BPV(pic),ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats

A PTEN inhibitor,BPV(pic),ameliorates early brain injury and...

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中国医师协会神经外科医师分会第六届全国代表大会

作者： John H Zhang 第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

The goal of this study was to investigate the role of phosphatase and tensin homolog deleted on chromosome ten(PTEN) in early brain injury after subarachnoid hemorrhage(SAH).The standard intravascular perforation mode... 详细信息

关键词： A PTEN inhibitor,BPV ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats pic

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Inflammation injury after experimental subarachnoid hemorrhage in rats and the effect of Adenosine A3 receptor activation

Inflammation injury after experimental subarachnoid hemorrha...

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中国医师协会神经外科医师分会第六届全国代表大会

作者：罗春霞第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

Inflammation response have been implicated in the pathogenesis of early brain injury after subarachnoid hemorrhage(SAH).Recently,adinosine A3R has attracted attention for its ability to modulate inflammation. In this ... 详细信息

关键词： SAH Inflammation injury after experimental subarachnoid hemorrhage in rats and the effect of Adenosine A3 receptor activation

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Neurotensin expressed by glioma-initiating cells affects clinical outcome in glioma patients

Neurotensin expressed by glioma-initiating cells affects cli...

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中国医师协会神经外科医师分会第六届全国代表大会

作者：易良第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

Malignant glioma is the most common and fatal tumor in central nervous system,with the poor prognosis even with the advanced *** new prognostic factors and molecular targets may contribute to the understanding of malignance progression and patient ***,we investigated the neurotensin(Nts) expression in a series of 116 patients with gliomas of different histology grades and primary cultured glioma initiating cells(GICs).The correlation between Nts expression and the prognosis was *** effect of NTS expression on GICs proliferation was also *** found that NTS expression was detected in 70.9%of malignant gliomas and was significantly(P=0.015) related with a poor *** analysis indicated that NTS expression(P=0.007) was independent predictors of poor ***,the results revealed that Nts was mainly expressed by GICs,not by differentiated glioma *** of NTS expression resulted in a significant reduction of GICs *** study indicated that the expression of Nts positively correlated with the histology grades of malignances and could be identified as a prognostic marker in patients with *** which are highly expressed in GICs promoted the proliferation of GICs in an autocrine fashion and might be a potential target to restrict self - renewal of GICs.

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