Background & Aims:The circadian clock presents daily rhythmicity to numerous crucial biological processes and its disruption is related to carcinogenesis in several kinds of *** a core circadian rhythm component,b...
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Background & Aims:The circadian clock presents daily rhythmicity to numerous crucial biological processes and its disruption is related to carcinogenesis in several kinds of *** a core circadian rhythm component,brain and muscle arnt-like protein 1(BMAL1)dysregulation has been shown to contribute to aberrant metabolism in human ***,the biological functions of BMAL1,especially its involvement in aberrant lipid metabolism in hepatocellular carcinoma(HCC),remain ***:The expression of BMAL1 and its clinical significance was determined in tissues and cell lines of *** addition,biological functions of BMAL1 in HCC cells and the underlying molecular mechanisms were explored both in vitro and in ***,therapeutic application of BMAL1 in the treatment of HCC was also ***:We established that BMAL1was often down-regulated in HCC cells primarily due to the up-regulation of ***-regulation of BMAL1 was remarkably linked to dismal survival in individuals with ***1 down-regulation enhanced HCC cell growth,as well as ***,through cooperating with EZH2,BMAL1 transcriptionally suppressed glycerol-3-phosphate acyltransferase mitochondrial(GPAM) expression,a pivotal enzyme involved in the regulation of lipid biosynthesis,leading to reduced levels lysophosphatidic acid(LPA),which has long been known as mediator of ***,treatment with SR8278,an activator of BMAL1,exhibited a therapeutic influence on ***:BMAL1 has as critical anti-oncogenic role in HCC,providing a strong research evidence for BMAL1 as a prospective HCC therapeutic target.
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