Background:Lead(Pb),as a widespread environmental pollutant,is known to cause a wide range of neurotoxic effects,including decreased intelligence quotient,cognitive deficits,poor attention span,and increased *** has l...
详细信息
Background:Lead(Pb),as a widespread environmental pollutant,is known to cause a wide range of neurotoxic effects,including decreased intelligence quotient,cognitive deficits,poor attention span,and increased *** has long been recognized as a neurodevelopmental *** blood-brain barrier(BBB) and blood-cerebrospinal fluid barrier(BCB) are known to be targets of Pb *** capillary endothelial cells with tight junctions(TJs)between adjacent cells,astrocyte end feet,and pericytes within the capillary basement constitute the structural basis of the *** plexus epithelial cells with tight junctions(TJs) between adjacent cells constitute the structural basis of the ***,the underlying mechanisms of Pb-induced reduction of TJ proteins of BBB and BCB are still *** way Pb enters into the brain parenchyma or cerebrospinal fluid can be classified into two categories:intercellular regions after breakdown TJ proteins and Pb transporter in the endothelial/epithelial cell ***,hemichannels of Connexin 43(Cx43),the most ubiquitously expressed gap junction proteins in the BBB and BCB,were found to be important pathways for many *** previous study,Cx43 expression was enhanced in the hippocampus,a major target of Pb-induced neurotoxicity,implying that Pb may accumulate in the hippocampus via Cx43 *** is nonreceptor protein tyrosine kinases that mediates the integrin signaling on the focal adhesion complex at the cell-toextracellular matrix *** kinase activity is required for both assembly and disassembly of TJ proteins in different epithelial *** addition,Src has long been known to interact with and phosphorylate Cx43 to promote downregulation of GJ communication and cause GJ disassembly,even channel *** phosphorylation was found to increase greater than other kinases in brain microvessels after Pb exposure by using a phosphoprotein antibody ***:This study was designed
暂无评论